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11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

Comparison between ligation-assisted and precutting endoscopic mucosal resection for small rectal neuroendocrine tumors: a CHASID study.

Ryou S, Jung Y, Kim DS et al. · 2026 · The Korean journal of internal medicine

Background/aims Few studies have compared modified endoscopic mucosal resection (EMR) techniques for small rectal neuroendocrine tumors (NETs). This study evaluated the clinical outcomes of ligation-assisted EMR (EMR-L) and precutting EMR…

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Negative / Null Result ReportMedicine

Therapy resistant hypertrophic lichen planus and its response to oral tofacitinib with a priori tissue cytokine expression: a real-world hospital-based study.

Sharath S, Sardana K, Khurana A et al. · 2025 · Archives of dermatological research

Background Although there are several reports on use of tofacitinib in lichen planus (LP), its usage in hypertrophic LP is sparse with no data on tissue cytokine expression. Methods We retrospectively analyzed the records of recalcitrant…

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Negative / Null Result ReportOpen accessMedicine

Refractory severe aplastic anemia in a child: treatment failure and access barriers in a low-resource setting.

Karaki Z, Chemaly C, Kotaich J et al. · 2025 · Annals of medicine and surgery (2012)

Introduction and importance Aplastic anemia (AA) is a rare but potentially fatal hematologic disorder in children, marked by bone marrow failure and pancytopenia. Early diagnosis and access to curative treatment such as hematopoietic stem…

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Negative / Null Result ReportOpen accessMedicine

Absence of lipopolysaccharide (LPS) expression in breast cancer cells.

de Miranda NFCC, Smit VTHBM, van der Ploeg M et al. · 2025 · Cellular oncology (Dordrecht, Netherlands)

The relationship between bacterial activity and tumorigenesis has gained attention in recent years, complementing the well-established association between viruses and cancer. A recent study employed immunodetection of lipopolysaccharide…

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Negative / Null Result ReportOpen accessMedicine

Use of baloxavir as adjunctive antiviral therapy to neuraminidase inhibitors in severely immunocompromised individuals infected with influenza.

Vetter P, Cabecinhas ARG, Schibler M et al. · 2026 · Antimicrobial agents and chemotherapy

Immunocompromised patients are at risk of developing severe influenza, with protracted viral shedding and development of resistance-associated mutations under antiviral treatment. We report a case series of severely immunocompromised…

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Negative / Null Result ReportMedicine

Leukocyte-Poor Platelet-Rich Plasma as a Treatment for Patellar Tendinopathy A Multicenter, Randomized Controlled Trial.

Herrero C, Wasterlain A, Bloom DA et al. · 2024 · Bulletin of the Hospital for Joint Disease (2013)

Purpose The purpose of this study was to compare regimens of eccentric exercise and dry-needling, with and without an ultrasound-guided leukocyte-poor platelet-rich plasma (LP-PRP) injection, in patients with patellar tendinopathy. Methods…

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Negative / Null Result ReportOpen accessMedicine

An analytical observational study for diagnostic accuracy of volume, conductivity & scatter (VCS) indices of neutrophils for diagnosis of sepsis in an emergency hospital setting.

Bharti A, Palta A, Bedi RK et al. · 2024 · The Indian journal of medical research

Background & objectives The newer technique using an innovative volume conductivity scatter (VCS) technology is emerging as a surrogate for sepsis diagnosis. The VCS technology offers a more objective method to measure cell volume (V),…

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Negative / Null Result ReportOpen accessMedicine

In Vitro Assessment of the Potential Effect of Vertical Peri-Implant Soft Tissue Thickness on Nonsurgical and Surgical Implant Surface Decontamination Methods.

Rahner A, Eickholz P, Gueth JF et al. · 2025 · Clinical oral implants research

Objectives In vitro analysis of the influence of vertical peri-implant soft tissue thickness (STT) on nonsurgical and surgical implant surface decontamination efficacy. Material and methods A total of 360 implants were dipped in indelible…

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Negative / Null Result ReportMedicine

Comparison of computed tomography findings between perianal tumors originating from the anal sacs and perianal glands in dogs.

Jeong J, Goh J, Nam C et al. · 2025 · Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association

Tumors originating from the anal sacs and perianal glands are common tumors of the perianal region. However, differentiation of perianal tumors based on CT findings remains challenging because perianal tumors can show overlapping CT…

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Negative / Null Result ReportOpen accessMedicine

Analysing the clinical outcomes between FIGO 2009 and 2023 staging for endometrial cancer-a single institution retrospective study.

Vuppu DP, Rajanbabu A, Nair IR et al. · 2025 · Ecancermedicalscience

The latest International Federation of Gynaecology and Obstetrics (FIGO) staging for endometrial cancer incorporated molecular profiles and histopathological factors into the basic staging framework. This study was done to determine its…

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Negative / Null Result ReportMedicine

Development of an evaluation and treatment strategy for olfactory neuroblastoma: a review of evidence from large-scale studies, including population-based and multicenter studies, and meta-analyses.

Ariizumi Y, Asakage T · 2024 · Japanese journal of clinical oncology

Olfactory neuroblastoma is a rare sinonasal malignancy arising from the olfactory epithelium that is characterized by skull base involvement and a modest natural history. Because of its rarity and long course, identification of independent…

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Negative / Null Result ReportMedicine

Immunonutrition to improve the quality of life of upper gastrointestinal cancer patients undergoing neoadjuvant treatment prior to surgery (NEOIMMUNE): double-blind randomized controlled multicenter clinical trial.

Markar S, Markar S, Mariette C et al. · 2025 · Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus

Background Malnutrition is common with esophagogastric cancers and is associated with negative outcomes. We aimed to evaluate if immunonutrition during neoadjuvant treatment improves patient's health-related quality of life (HRQOL) and…

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Negative / Null Result ReportOpen accessMedicine

Is fixation of a single end of flail segment rib fractures enough?

Perugini A, Iandoli J, Pelz N et al. · 2025 · Trauma surgery & acute care open

Background Segmental rib fractures in blunt thoracic trauma present with increased morbidity and mortality with an association of increased pulmonary insult and concomitant injuries. There is a paucity within the literature regarding the…

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Negative / Null Result ReportMedicine

Fundus blood flow density changes in the smoking population by artificial intelligence-based optical coherence tomography angiography.

Zhang LY, Li QJ, Zhou Q et al. · 2025 · International journal of ophthalmology

Aim To determine whether chronic smoking affects fundus blood flow density using optical coherence tomography angiography (OCTA) based on artificial intelligence (AI). Methods All participants underwent a comprehensive ophthalmological…

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Negative / Null Result ReportOpen accessMedicine

Evaluation of spot urine CA 19 - 9/creatinine ratio in diagnosis and management of hydronephrosis in children: a prospective study.

Kutukoglu MU, Altuntas T, Sekerci CA et al. · 2025 · BMC pediatrics

Background To demonstrate that the CA19-9/creatinine level could be a potential biomarker in children with obstruction by including ureteropelvic junction obstruction (UPJO) patients and comparing them not only with healthy controls but…

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Negative / Null Result ReportOpen accessMedicine

Neuromuscular and Neurocognitive Performance Associated with ACL Injury Risk in Youth Handball Players: A Prospective Cohort Study.

Sinka GC, Pavlik A, Mayer Á et al. · 2026 · Sports (Basel, Switzerland)

Background Anterior cruciate ligament (ACL) injuries in youth athletes are multifactorial, and the relative contributions of neuromuscular and neurocognitive variables remain inadequately comprehended. Methods In this prospective cohort…

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Negative / Null Result ReportMedicine

Real-World Patient Eligibility and Feasibility of Transcatheter Edge-to-Edge Repair or Replacement Interventions for Tricuspid Regurgitation.

Abushouk A, Layoun H, Harb SC et al. · 2024 · Journal of cardiac failure

Novel transcatheter therapies for tricuspid regurgitation (TR) appear promising, yet their applicability to an all-comer TR population remains unclear. We aimed to assess the feasibility of emerging transcatheter tricuspid therapies in a…

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Negative / Null Result ReportOpen accessMedicine

Ivermectin to reduce malaria transmission- safety and efficacy results from the BOHEMIA cluster randomized trial in Mozambique.

Chaccour C, Nicolas P, Martinho S et al. · 2025 · EClinicalMedicine

Background Endectocides are a novel vector control tool that reduce the survival and fertility of blood sucking arthropods that feed upon treated humans or animals. Ivermectin mass drug administration is under evaluation as a complementary…

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