11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Taniajura N, Rincon C, Kennedy S et al. · 2026 · Addictive behaviors reports
Research has demonstrated that exposure to alcohol-related cues (e.g., sight or smell of a preferred beverage) elicits heightened self-reported craving and psychophysiological responses, including changes in heart rate (HR) and heart rate…
View details →Barrera G, Albiach-Serrano A, Guillén-Salazar F · 2024 · Animal cognition
Studies have shown that horses are sensitive to human attentional cues. Also, there is some evidence that they might be able to infer the knowledge state of a human and communicate intentionally with us. However, this ability is not fully…
View details →Bansal M, Mehta A, Morris DL et al. · 2025 · Proceedings (Baylor University. Medical Center)
Background This study sought to assess the outcomes of pulmonary embolism (PE) admissions at teaching and nonteaching hospitals in the month of July, when new trainees begin their training in the United States. Methods During 2016-2021,…
View details →Ruiz VH, Gill CM, Nicolau DP · 2024 · The Journal of antimicrobial chemotherapy
Objectives To evaluate the efficacy of human-simulated regimens (HSRs) of ceftazidime, ceftazidime/avibactam, imipenem, imipenem/relebactam, meropenem and meropenem/vaborbactam in a murine thigh infection model against serine…
View details →Schaefer M, Liedtke C, Enge S · 2025 · Scientific reports
Recent reports challenge the view that placebos need to be given in deception. Numerous studies report remarkable effects when giving placebos honestly in an open way. However, the mechanisms of open-label placebos still remain to be…
View details →Tortolani AF, Kunigk NG, Sobinov AR et al. · 2025 · Journal of neural engineering
Objective . As brain-computer interface (BCI) research advances, many new applications are being developed. Tasks can be performed in different virtual environments, and whether a BCI user can switch environments seamlessly will influence…
View details →Rogers ER, Sankarasubramanian V, Kyi WHT et al. · 2025 · Journal of pain research
Purpose The analgesic mechanisms and neurophysiological effects of spinal cord stimulation (SCS) and dorsal root ganglion stimulation (DRGS) are poorly understood. In this pilot repeated-measures study, we used quantitative sensory testing…
View details →Mauz JB, Rieland H, Berliner D et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Considerate patient selection is vital to ensure the best possible outcomes after transjugular intrahepatic portosystemic shunt (TIPS) insertion. However, data regarding the impact of intrapulmonary vascular dilatations…
View details →Seaman RW Jr, Shariatzadeh N, Salinas KA et al. · 2026 · Drug and alcohol dependence
Background Stimulant-opioid co-use has surged in the United States, with methamphetamine use among people who use opioids increasing 82.6 % from 2015 to 2017. This trend contributes to rising overdose deaths, marking a "fourth wave" of the…
View details →Lilley A, Chiapponi C, Prosperi A et al. · 2026 · Vaccines
Background/Objectives : Influenza A viruses cause seasonal epidemics of respiratory infections in humans, the severity of which can be mitigated by influenza vaccine use. Influenza A viruses circulating in pigs continue to pose a pandemic…
View details →Ng MK, Mastrokostas PG, Rodriguez AN et al. · 2025 · Journal of craniovertebral junction & spine
Context Semaglutide, a glucagon-like protein-1 receptor agonist used in diabetes and obesity management, has demonstrated perioperative benefits in other surgical populations. However, its role in spine surgery remains unclear. Aims This…
View details →Pilas LB, Gur O, Berger G · 2023 · The Israel Medical Association journal : IMAJ
Background In the past decade, numerous new imaging and laboratory tests have been implemented that significantly contribute to improved medical diagnostic capabilities. However, inappropriate utilization, which occurs on a large scale,…
View details →Jones CMP, Lin CC, Zadro J et al. · 2024 · Brazilian journal of physical therapy
Background The Brief Pain Inventory-Interference Subscale (BPI-IS) is a subscale of the BPI assessment tool developed to rapidly assess the impact of a person's pain on their function. It is uncertain whether it has one or two factors, and…
View details →Risi M, Greco G, Masciocchi S et al. · 2024 · Journal of neurology
Background Live cell-based assay (LCBA) is the gold standard for MOG-IgG detection, and fixed CBA (FCBA) is a widely used commercial alternative. Recent criteria attributed a diagnostic value to MOG-IgG titration with both LCBA and FCBA,…
View details →Ilmakunnas I, Sten-Gahmberg S · 2026 · Journal of aging & social policy
Flexible partial retirement schemes are intended to give individuals the opportunity to reduce working hours before moving into full retirement, the expectation being that the reduced workload will contribute to postponed old-age…
View details →Stapley V, Anderson RS, Saunders K et al. · 2025 · Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
Introduction Previous research suggests that the electroretinogram (ERG) is reduced and delayed in non-pathological myopia. However, the invasive nature of the electrode and cumbersome equipment required has prevented the widescale uptake…
View details →Fowler PV, Keall H, Kennedy D et al. · 2025 · The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
ObjectivesTo investigate cleft laterality dental arch relationship outcomes of children with non-syndromic complete unilateral cleft lip and palate (UCLP) in New Zealand.DesignA retrospective nationwide study.SettingsVirtual 3D orthodontic…
View details →Rachuene PA, Dey R, Kauta NJ et al. · 2024 · SICOT-J
Background Pre-operative planning for reverse shoulder arthroplasty (RSA) poses challenges, particularly when dealing with glenoid bone loss. This modified Delphi study aimed to assess expert consensus on RSA planning processes and…
View details →Iwagami S, Miyai H, Nishihata M · 2026 · Research and reports in urology
Purpose Transperineal prostate biopsy is essential for diagnosing prostate cancer; however, infection remains a clinically significant issue. We evaluated the safety and outcome of a single, prophylactic oral dose of cefaclor 500mg during…
View details →Ashaibi NA, Mason AG, Hector MP et al. · 2025 · Clinical and experimental dental research
Objectives Dental pain of odontogenic origin can be difficult to accurately locate to a specific tooth. This study aimed to determine how effectively volunteers could locate electrical stimuli applied to teeth in both the anterior and…
View details →Schlötelburg W, Hartrampf PE, Kosmala A et al. · 2024 · Endocrine
Purpose We aimed to evaluate the prognostic potential of baseline [ 18 F]FDG PET/CT for overall survival (OS) in patients with adrenocortical carcinoma (ACC). Methods We performed a retrospective analysis of 67 treatment-naïve ACC patients…
View details →Byington CG, Goodman AM, Allendorfer JB et al. · 2024 · Epilepsia
Objective The uncinate fasciculus (UF) has been implicated previously in contributing to the pathophysiology of functional (nonepileptic) seizures (FS). FS are frequently preceded by adverse life events (ALEs) and present with comorbid…
View details →Mohammadzadeh M, Abdi F, Hadi S et al. · 2026 · BMC nutrition
Background A high-quality diet is an important strategy for preventing chronic diseases, including cancer. The Nutrient Rich Food Score (NRFS) is a very useful index that can compare the value of key micronutrients and macronutrients per…
View details →Soufi R, Salamzadeh J, Alavi Darazam I et al. · 2025 · Iranian journal of pharmaceutical research : IJPR
Background Vancomycin is commonly used in intensive care units (ICUs), but its optimal dosage in patients with acute kidney injury (AKI) remains uncertain. This study aimed to evaluate vancomycin's pharmacokinetic and pharmacodynamic…
View details →Ullal SD, Thomas AG, Acharya SD et al. · 2026 · Pharmacology research & perspectives
Epilepsy is a common neurologic disorder; its incidence in childhood is 2.5 per 1000 children. Levetiracetam (LEV) is an antiepileptic drug with a broad spectrum of action used in localized and generalized epilepsies in both adults and…
View details →Hawkey AB, Fan R, Nwachukwu K et al. · 2025 · Neurotoxicology and teratology
Neurotoxic risks in the environment come from many toxicants, which are often found together in complex mixtures. However, nearly all experimental studies evaluate one chemical at a time. Neurobehavioral effects of developmental exposure…
View details →Jacover A, Beller T, Mahamid N et al. · 2025 · Annals of surgical oncology
Introduction Neoadjuvant therapy (NT) is generally preferred over upfront surgery for borderline resectable pancreatic ductal adenocarcinoma (BR-PDAC), but many patients fail to reach surgical resection. This study evaluates real-world…
View details →Tanisaka Y, Ryozawa S, Mizuide M et al. · 2025 · Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
Endoscopic sphincterotomy (EST) is challenging for patients with surgically altered anatomy (SAA). The blades of conventional sphincterotomes designed for SAA do not always face the correct direction of EST. We aimed to evaluate the…
View details →Sandby K, Magkos F, Chabanova E et al. · 2024 · Clinical nutrition (Edinburgh, Scotland)
Background & aims In recent years, epidemiological studies have reported links between the consumption of fermented dairy products, such as yogurt, and health; however, evidence from human intervention trials is scarce and inconsistent. We…
View details →Buck AN, Fleiner T, Rosskothen-Kuhl N et al. · 2026 · Trends in hearing
It is widely known that users of cochlear implants (CIs) often show deficits in binaural hearing. In particular, interaural time difference (ITD) discrimination tends to be substantially worse in CI users. However, only very few studies…
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