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Browse the failure-mode index

11,416 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Microsurgical Denervation of the Penis for Lifelong Premature Ejaculation: A Prospective Multicenter Study Evaluating Technique Modification and Early Clinical Outcomes.

Almekaty K, Alhefnawy M, Ismael A et al. · 2026 · Urology

Objective To prospectively assess the clinical outcomes and safety of microsurgical denervation of the penis (MSDP) for treatment of lifelong premature ejaculation (LPE); and to examine the impact of transitioning from partial to more…

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Negative / Null Result ReportMedicine

Dento-facial changes and oral health-related quality of life assessment in management of anterior crossbite in mixed dentition: a randomized clinical trial.

Salem AS, Albelasy NF, El-Bialy AA · 2026 · The Angle orthodontist

Objectives To compare the effectiveness of clear aligner (CA) vs removable inclined plane (RP) in improving the dentofacial changes and oral health-related quality of life (OHRQoL) in children with anterior crossbite in the mixed…

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Negative / Null Result ReportMedicine

Size Dependent Effects of Aluminum Oxide Particles on Tissue Accumulation and Antioxidant Enzyme Activities of Oreochromis niloticus.

Tuncsoy M, Tuncsoy B · 2026 · Bulletin of environmental contamination and toxicology

Aluminum (Al) is a widely occurring element in nature and is the most abundant element in the earth's crust after oxygen and silicon. In this study, metal accumulation levels in the gills, liver and muscle tissues and liver SOD, CAT and…

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Negative / Null Result ReportOpen accessMedicine

Short-term CoQ10 supplementation reduces markers of cardiac stress in soccer players following heavy exercise: A randomized double-blind placebo-controlled trial.

Rahimi MR, Morton AB, Golpasandi H et al. · 2025 · BMC sports science, medicine & rehabilitation

Background Coenzyme Q10 (CoQ10), a vital mitochondrial antioxidant, may enhance cardiovascular recovery and delay fatigue in athletes. This double-blind, randomized, placebo-controlled trial investigated CoQ10's effects on cardiac stress…

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Negative / Null Result ReportMedicine

Maternal Response to Therapeutic Plasma Exchange in Early Gestation: A Case Series of Thrombotic Microangiopathies and Neurological Disorders.

Karaaslan O, Türkyılmaz G, Hacıoğlu L et al. · 2026 · Biomedicines

Background/Objectives: Therapeutic plasma exchange (TPE) is an extracorporeal treatment used in thrombotic microangiopathies (TMAs) and various autoimmune and neurological disorders. However, data regarding its use during early pregnancy…

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Negative / Null Result ReportMedicine

Enhancing Immunity and Gut Microbiota Balance with Black Soldier Fly Larvae (BSFL) Meal: A Sustainable Feed Ingredient That Maintains Growth Performance in Pekin Ducks.

Long L, Liu G, Gao G et al. · 2026 · Insects

The effects of substituting soybean meal with black soldier fly larvae (BSFL) meal on the growth performance, immunological response, intestinal morphology, and gut microbiota of Pekin ducks were assessed. A total of 150 one-day-old Pekin…

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Negative / Null Result ReportOpen accessMedicine

The scramblase anoctamin 9 controls the immune response in lymphocytes.

Schreiber R, Ousingsawat J, Kunzelmann K · 2026 · Cellular and molecular life sciences : CMLS

We previously reported a loss of T cell activation following knockdown of the phospholipid scramblase and ion channel ANO9 (TMEM16J) in human Jurkat lymphocytes. We have now analyzed in detail the role of ANO9 in Jurkat ANO9 knockout cells…

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Negative / Null Result ReportMedicine

Mechanistic-statistical model for the expansion of ash dieback.

Fritsch C, Grosdidier M, Gégout-Petit A et al. · 2026 · Theoretical population biology

Hymenoscyphus fraxineus is an invasive forest fungal pathogen that induces severe dieback in European ash populations. The spread of the disease has been closely monitored in France by the forest health survey system which has made it…

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Negative / Null Result ReportMedicine

Assessing the Effectiveness of Multidisciplinary Interventions in Reducing Catheter-Associated Urinary Tract Infection: An Interrupted Time Series Modeling Approach.

Wills W, Rosever K, Bugajski A et al. · 2026 · Journal of nursing care quality

Background Recommendations support multi-interventional catheter-associated urinary tract infection (CAUTI) reduction programs; however, identifying specific interventions with significant impact may be beneficial in resource-limited…

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Negative / Null Result ReportMedicine

Exploring the Mediating Role of Social Media and Gaming in the Relationship between Adolescents' Feelings of Loneliness, Ostracism and Internalizing and Externalizing symptoms.

Bruneel S, Sjöblom J, Lagerström M et al. · 2026 · Child psychiatry and human development

Social outsiderhood - particularly loneliness and ostracism - has a significant impact on mental health issues such as internalizing symptoms (e.g., depression, anxiety) and externalizing symptoms (e.g., aggression, conduct problems). Yet,…

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Negative / Null Result ReportMedicine

Evaluation of rotational profile and foot loading in the uninvolved leg of children with unilateral clubfoot treated with foot abduction orthoses.

Lawing CR, Bailey CE, Garg S et al. · 2026 · Journal of pediatric orthopedics. Part B

Ponseti treatment of congenital clubfoot utilizes foot abduction bracing to prevent recurrence. In unilateral clubfoot, families have expressed concern about inducing deformity in the uninvolved leg. This study evaluated rotational…

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Negative / Null Result ReportMedicine

Improving Medication Adherence in Kidney Transplant Recipients Through Educational Intervention and Monitoring: A Randomized Clinical Trial.

Heinrich de Oliveira C, Schweig A, Gonçalves BP et al. · 2026 · Transplantation proceedings

Background Kidney graft survival after transplantation is highly dependent on continuous adherence to immunosuppressive therapy. Poor adherence is a significant cause of graft loss, and educational interventions to optimize care have been…

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Negative / Null Result ReportOpen accessMedicine

The association between sleep quality and postoperative pain after half-impacted mandibular third molar extraction: comparison of three statistical models.

Hu L, Zhao C, Wang T et al. · 2026 · BMC oral health

BACKGROUND: Pain is the common complication after tooth extraction, while the reasons behind it still remains. Insomnia, another prevalent issue, negatively affects physical, mental health, and quality of life. The relations between…

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