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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportOpen accessMedicine

The use of cellphone based automated pupillometry to quantify opioid withdrawal in patients receiving treatment for opioid use disorder.

Evonko CJ, Vigilante KC, Leli NB et al. · 2026 · Journal of substance use and addiction treatment

Introduction Overdose deaths attributed to opioid misuse resulted in over 50,000 deaths in 2024. Opioid agonist therapies such as methadone and buprenorphine are effective for the treatment of opioid use disorder (OUD). Yet, patient…

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Negative / Null Result ReportOpen accessMedicine

Effectiveness of dilution ventilation in mitigating occupational exposure to volatile organic compounds (VOCs) at the breathing zone of nail technicians: a simulation study.

Salari S, Fazeli-Tabar S, Karimi A et al. · 2026 · Scientific reports

Volatile Organic Compounds (VOCs) from nail products pose potential health risks to technicians and clients. The present study investigates the exposure of nail technicians to VOC and assesses the effectiveness of dilution ventilation in…

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Negative / Null Result ReportOpen accessMedicine

Motives of Children for Digital Gaming and Physical Activity and Their Parents' Perceptions: Cross-Sectional Matched-Pair Study.

Wachholz F, Gamper N, Kruse S et al. · 2026 · JMIR pediatrics and parenting

Background Physical activity (PA) is essential for the healthy development of children. However, the pervasive presence of digital technologies has made digital gaming (DG) a prominent part of children's everyday lives. As children grow up…

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Negative / Null Result ReportOpen accessMedicine

Extent of Pelvic Lymph Node Dissection at Partial Cystectomy: Effect on Cancer-Specific Mortality.

Longoni M, Marmiroli A, Falkenbach F et al. · 2026 · International journal of urology : official journal of the Japanese Urological Association

Introduction We assessed the extent of pelvic lymph node dissection (PLND) at partial cystectomy (PC) according to PC eligibility (≤cT2 stage, tumor ≤ 3 cm and segmental resection possible) and tested its effect on cancer-specific…

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Negative / Null Result ReportOpen accessMedicine

Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.

Li J, Li A, Jiao J et al. · 2025 · Scientific reports

To evaluate effects of 10-day high-definition transcranial direct current stimulation (HD-tDCS) over the dorsal medial prefrontal cortex (DMPFC) in patients with chronic insomnia. Fifty-five chronic insomnia patients were randomized into…

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Negative / Null Result ReportOpen accessMedicine

Men talk less than women during multitasking.

Szameitat AJ, Szameitat DP · 2026 · Psychological research

Contrary to the widespread stereotype that women are better at multitasking than men, no consistent sex differences in multitasking abilities between males and females have been found. We developed a novel multitasking paradigm consisting…

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Negative / Null Result ReportMedicine

Plasmatic variability of direct oral anticoagulants in people with atrial fibrillation and previous gastric surgery: a pilot case series.

Romoli M, Vitiello M, Lotti EM et al. · 2025 · Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

Background Data on cardioembolic prevention with direct oral anticoagulants (DOAC) in atrial fibrillation (AF) patients with previous gastric surgery are lacking. We report inter- and intra-individual differences in DOAC concentration in…

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Negative / Null Result ReportOpen accessMedicine

Association between Vitamin D Receptor Polymorphisms, Tight Junction Proteins and Clinical Features of Adult Patients with Atopic Dermatitis.

Grieco T, Moliterni E, Paolino G et al. · 2024 · Dermatology practical & conceptual

Introduction Few studies have explored the intricate connections between vitamin D receptor (VDR) gene polymorphisms, VDR, tight junction (TJ) protein expression and clinical features of atopic dermatitis (AD). Methods From 43 adult AD…

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Negative / Null Result ReportMedicine

A qualitative study on perceptions of adolescents' sexual and reproductive health education in Yogyakarta, Indonesia.

Sikoki B, Larastiti C, Suriastini NW et al. · 2024 · International journal of adolescent medicine and health

Introduction Sexual and reproductive health (SRH) education in Yogyakarta, Indonesia, is contentious due to societal and religious taboos in the Javanese Muslim community and being misunderstood as a potential catalyst for the premarital…

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Negative / Null Result ReportOpen accessMedicine

Real-world effectiveness of vonoprazan-based regimen versus rabeprazole-based dual therapy for <i>Helicobacter pylori</i> eradication in a high-resistance, multi-ethnic region: a multicenter study in Guizhou, China.

Huang Y, Zheng J, Yang Z et al. · 2026 · Frontiers in medicine

Introduction While vonoprazan-amoxicillin dual therapy has achieved > 90% eradication rates for Helicobacter pylori (H. pylori) in clinical trials, its effectiveness in "real-world" regions with high primary antibiotic resistance and…

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Negative / Null Result ReportOpen accessMedicine

A consensus exercise to inform the future of National Health Service General Dental Services using a modified-Delphi technique.

Chestnutt IG, Pattinson R, Brocklehurst P et al. · 2026 · British dental journal

Background Problems relating to the commissioning and delivery of National Health Service (NHS) General Dental Services (GDS) have been well-documented.Objectives This study aimed to gain consensus on issues deemed of importance to the…

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Negative / Null Result ReportMedicine

Primary outcomes and anticipated effect sizes in randomised clinical trials assessing peripheral and truncal nerve blocks: a systematic scoping review.

Sorenson S, Flyger SSB, Pingel L et al. · 2025 · British journal of anaesthesia

Background Peripheral and truncal nerve blocks provide effective analgesia facilitating perioperative care. However, thresholds for clinically relevant effects remain undetermined and are left for clinicians to choose. These choices are…

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Negative / Null Result ReportOpen accessMedicine

Effects of Multimodal and Unimodal Physical Training Interventions on Visual Function in Glaucoma and Elderly Controls - A Pilot Study.

Moffack Djuloun C, Al-Nosairy KO, Beyer R et al. · 2026 · Clinical ophthalmology (Auckland, N.Z.)

Purpose This study aimed to investigate the effects of a 12-week multimodal motor-cognitive and resistance training (MMI) compared to a unimodal resistance training intervention (UMI) on static and dynamic visual function in glaucoma (GLA)…

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