490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Seyama S, Uwamino Y, Yoshihara K et al. · 2026 · Diagnostic microbiology and infectious disease
Accurate subspecies identification and determination of macrolide resistance status are crucial for the treatment of Mycobacterium abscessus complex (MABC) infections. In recent years, a kit that uses DNA chromatography to differentiate…
View details →Song M, Zhang Z, Huang H et al. · 2026 · The American journal of case reports
BACKGROUND Spinal tuberculosis is difficult to diagnose in patients undergoing maintenance hemodialysis (MHD) because of immunosuppression, atypical clinical manifestations, and the limited sensitivity of conventional microbiological…
View details →Yang DN, Xu YN, Niu Y et al. · 2025 · Scientific reports
The pleural fluid carcinoembryonic antigen (CEA) test is a diagnostic tool for malignant pleural effusion (MPE). Light's criteria are an important method for the differential diagnosis of pleural effusion. This study aimed to analyze the…
View details →Ali O, Abbas R, Shaikh N et al. · 2025 · Cureus
Cerebral venous sinus thrombosis (CVST) is a rare, potentially life-threatening condition that presents with variable symptoms such as headache, visual disturbance, and seizures, often mimicking an arterial stroke or intracranial lesion.…
View details →Montaño AM, Robledo C, Galvis-Ayala JC et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Purpose To determine diagnostic validity of MALDI-TOF MS (VITEK MS) system for detecting Klebsiella pneumoniae carbapenemases (KPC)-type carbapenemases by identifying the 11,109 Da peak in the mass spectrum generated for species…
View details →Olbrich A, Motekallemi A, Deschka H et al. · 2025 · Interdisciplinary cardiovascular and thoracic surgery
Objectives Driveline infection (DLI) is a common complication in patients with left ventricular assist devices. This complication can seriously undermine quality of life while on left ventricular assist devices. Current diagnosis of a DLI…
View details →Yu HJ, Kim JA, Song HM et al. · 2026 · Journal of Korean medical science
Background Rapid and accurate detection of Mycobacterium tuberculosis complex (MTBC) in acid-fast bacilli (AFB)-positive cultures is crucial for effective patient management and transmission control. This study assessed the diagnostic…
View details →Loeb SA, Tharp DL, Zawieja SD et al. · 2026 · Journal of cardiovascular pharmacology
Over 30 million individuals globally are afflicted with heart failure with preserved ejection fraction (HFpEF). Despite this substantial figure, treatment options for HFpEF remain limited. This is largely attributed to the variability in…
View details →Daix-Moreux M, El Hajj H, Schérier S et al. · 2026 · Gynecologic oncology
Objective Assess the accuracy of preoperative PET-CT in detecting para-aortic nodal metastasis in patients with locally-advanced cervical cancer, using routine laparoscopic para-aortic lymphadenectomy and evaluate its impact on patient…
View details →Patterson KN, Reynolds MM, Lueder GT · 2026 · American journal of ophthalmology case reports
Purpose To report our findings in a patient with an atypical case of supertemporal iris and retinal coloboma, and to assess its systemic associations and potential genetic causes. Observations A premature female infant born at 31 weeks…
View details →Puppo I, Vardanyan A, Shahsuvaryan G et al. · 2025 · The American journal of case reports
BACKGROUND Down syndrome, or trisomy 21, is one of the most common chromosomal disorders associated with intellectual disability. Prenatal screening is a proactive approach to identify fetuses with common chromosomal abnormalities.…
View details →Mucci TJ, Adam JA, Hirsa AH · 2026 · Soft matter
Modeling the flow of insoluble surfactant monolayers undergoing rapid expansion and compression remains a long-standing challenge in hydrodynamics. In a recent letter, compressible flow of a DPPC monolayer in the coexisting…
View details →Kaya B, Can E, Karakurt Y et al. · 2026 · Advances in neonatal care : official journal of the National Association of Neonatal Nurses
Background Early-onset neonatal sepsis (EOS) remains a diagnostic challenge because clinical signs are nonspecific and blood cultures, although the diagnostic gold standard may yield false-negative results due to low blood volumes or…
View details →Rosiles T, Nguyen M, Calin-Jageman RJ et al. · 2026 · eNeuro
Forming a long-term memory requires changes in neuronal transcription. What happens, though, as the memory is forgotten? And how does the transcriptional state relate to the maintenance and recall of the long-term memory? To answer these…
View details →McGuier M, Bragg E, Holtzheimer P et al. · 2026 · eNeuro
There is a critical need for robust and reliable preclinical models for posttraumatic stress disorder (PTSD) to better understand pathophysiological mechanisms and support the development of novel treatments. The single prolonged stress…
View details →Hartady T, Sugandi SD, Viqih M · 2026 · Veterinary sciences
Poultry disease outbreaks are frequently multifactorial, involving complex interactions between infectious agents and environmental stressors. This report describes a case of avian influenza (AI) co-infection in a commercial broiler farm…
View details →İpek Demir K, Yılmaz D, Güvenir FA et al. · 2026 · Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Background and objective Adverse drug reactions (ADRs) are a serious public health problem. This study aimed to evaluate reaction characteristics and diagnostic test results in pediatric patients in whom suspected drug allergy was…
View details →Yanagihara K, Nagata K, Yamakawa T et al. · 2025 · Cancers
Backgrounds : Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is a critical predictive biomarker for immune checkpoint inhibitor (ICI) therapy in triple-negative breast cancer (TNBC). However, prolonged storage of…
View details →Witkin JM, Pandey KP, Smith JL · 2022 · Pharmacology, biochemistry, and behavior
Pharmacological modulation of glutamate has long been considered to be of immense therapeutic utility. The metabotropic glutamate receptors (mGluRs) are potential targets for safely altering glutamate-driven excitation. Data support the…
View details →Abdelmalek MF, Sanyal AJ, Nakajima A et al. · 2024 · Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
Background & aims Pegbelfermin is a polyethylene glycol-conjugated analog of human fibroblast growth factor 21, a nonmitogenic hormone that regulates energy metabolism. This phase 2b study evaluated 48-week pegbelfermin treatment in…
View details →He X, Kratochwil N, Ariño-Estrada G et al. · 2026 · Physics in medicine and biology
Positron emission tomography (PET) image quality is partially determined by PET detector performance, which can be improved by increasing the optical photon harvest from scintillator to photodetector. Due to the steep index mismatch at…
View details →Adepoju D, Ohlsson JI, Klingström T et al. · 2026 · Genetics, selection, evolution : GSE
Background In genetic terms, the history of a population can be described by its effective population size over time. We know that domestic cattle have gone through dramatic changes in recent history, including intensifying selection in…
View details →Ilbag P, Rismanchian M, Yazdanirad S · 2026 · Scientific reports
The purpose of using electroplating is the high cost of corrosion of metal equipment. However, the dangers of this process are the basis for using industrial hygiene control methods in this industry. The aim of this study is to…
View details →Ducharme MT, Elmenawi KA, Poilvache H et al. · 2026 · The Journal of arthroplasty
Introduction Periprosthetic joint infections (PJI) are complex to manage and frequently result in prolonged hospitalization while awaiting outpatient antibiotic therapy coordination. Moving this work to the preoperative setting for…
View details →Bigirimana D, Hu N, Soo J et al. · 2026 · Ophthalmology. Glaucoma
Purpose To assess the cost-effectiveness of Xen45 Gel Stent (XGS) compared with trabeculectomy for the surgical management of open angle glaucoma in the United States Medicare system. Design Cost-utility analysis using safety and efficacy…
View details →Ganesh A, Smith EE, Mostert J et al. · 2026 · Neurology
Background and objectives The cost and complexity of phase 2 randomized-controlled trials (RCTs) hinder further development of promising treatment candidates for Alzheimer disease (AD). The Simon Two-Stage futility trial design, originally…
View details →Radha S, Arends M, Kislinger G et al. · 2026 · PLoS biology
Rapid information processing in complex organisms depends on myelin, which consists of a multilamellar membrane that tightly adheres to the axonal surface along the internode and at paranodal loops, where specialized adhesion proteins…
View details →El Hayek M, Koop A · 2026 · Obesity surgery
Gastroesophageal reflux disease (GERD) is a frequent postoperative concern after bariatric surgery, particularly following laparoscopic sleeve gastrectomy (LSG). This study aimed to identify clinical factors associated with GERD in…
View details →Xu Z, Guo Y, Shao Y et al. · 2026 · Journal of affective disorders
Background Differentiating the depressive phase of bipolar disorder (BD) from major depressive disorder (MDD) remains a significant clinical challenge. As CACNA1C is a prominent susceptibility gene for BD across diverse populations, this…
View details →Hamidi F, Muhler F, Skopp G et al. · 2026 · Clinical research in cardiology : official journal of the German Cardiac Society
Background Out-of-hospital cardiac arrest (OHCA) is associated with poor outcomes and presents a considerable treatment challenge. Here, we investigated the association of prior beta-blocker treatment with outcomes in patients with OHCA.…
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