11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Vinyard DJ, Govindjee G · 2024 · Photosynthesis research
Photosystem II (PSII) uses light energy to oxidize water and to reduce plastoquinone in the photosynthetic electron transport chain. O 2 is produced as a byproduct. While most members of the PSII research community agree that O 2…
View details →Halalsheh H, Odeh N, Kiswani A et al. · 2026 · Cancers
Background Accurate staging is vital for optimizing outcomes in pediatric rhabdomyosarcoma (RMS). While [ 18 F]-FDG PET/CT is increasingly utilized, its specific impact on clinical management and its prognostic value compared to…
View details →Ito S, Takano C, Hoque SA et al. · 2025 · Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
The BioFire FilmArray® Gastrointestinal (GI) Panel, a widely used diagnostic tool, is designed to detect the genetic material of 22 common pathogens responsible for gastroenteritis, including viruses, bacteria, and parasites. It can detect…
View details →Miao J, Xu Y, Qiao F et al. · 2026 · Oncology letters
The present prospective study aimed to investigate whether gallium-68-labeled fibroblast activation protein inhibitor-04 ( 68 Ga-FAPI-04) positron emission tomography (PET)/magnetic resonance imaging (MRI) could provide notably increased…
View details →Arcieri F, Vasta A, Sorrenti S et al. · 2026 · Journal of clinical medicine
Background: Congenital cytomegalovirus (cCMV) infection is a leading cause of neonatal morbidity. This retrospective study aimed to evaluate the efficacy of valacyclovir in reducing vertical transmission after primary maternal CMV…
View details →Shi J, Li G, Tang W et al. · 2026 · Frontiers in oncology
Adenocarcinoma originating from the anal gland with immunohistochemical expression of GATA3 and TTF-1 (ACAGGT) is a rare entity. This report describes an 80-year-old female patient who detected a perianal mass without an obvious cause 10…
View details →K K V, P R A, Rao BK et al. · 2024 · Rapid communications in mass spectrometry : RCM
Rationale The exploration of the gut microbiome and related metabolites holds an exciting future in health science. The challenges associated with fecal sample testing are proper sample collection, sterile transportation, optimal transport…
View details →Burrows P, Brown RA, Samuelsen A et al. · 2025 · Antimicrobial stewardship & healthcare epidemiology : ASHE
Objective To assess whether antibiotic duration (AD) and one-year antibiotic-free days (AFD) are associated with key in-hospital and post-discharge outcomes among critically ill adults. Design Prospective observational study. Setting…
View details →Sun L, Jiang Y, Ma X et al. · 2026 · Frontiers in pharmacology
Background Currently, postoperative nonsteroidal anti-inflammatory drugs-associated kidney damage in hypertensive patients remains undetermined. This study aimed to examine renal safety of short-term post-surgery use of flurbiprofen axetil…
View details →Sachetto ATA, Mackman N · 2024 · Research and practice in thrombosis and haemostasis
Background Tissue factor (TF) is the primary cellular initiator of the blood coagulation cascade. Increased levels of TF expression on circulating monocytes or on extracellular vesicles (EVs) are associated with thrombosis in a variety of…
View details →De Ryst JE, Bergström S, Mravinacova S et al. · 2026 · Fluids and barriers of the CNS
Background Aquaporin-4 (AQP4) is crucial for brain fluid regulation and glymphatic system function. Idiopathic normal pressure hydrocephalus (INPH) is characterized by impaired CSF flow and is treated with shunt surgery. This study…
View details →Liu D, Yan Q, Qin X et al. · 2025 · Biochimica et biophysica acta. Bioenergetics
Photosystem I (PSI) is a large membrane photosynthetic complex that harvests sunlight and drives photosynthetic electron transport. In both green algae and higher plants, PSI's ultrafast energy transfer and charge separation kinetics have…
View details →S R S, Holla R, Rao M et al. · 2026 · The Indian journal of medical research
Background and objectives The gold standard for diagnosing malaria is peripheral smear. Histidine-rich protein 2 (HRP2)-based rapid diagnostic tests (RDTs) are particularly used for P. falciparum (pf) infections. These tests are easily…
View details →N R, Sivamani H, Sivaraman A et al. · 2024 · Cureus
This report presents the case of vaginal foreign body (FB) in a seven-year-old girl with recurrent genitourinary symptoms that went unrecognized for two years. Despite thorough evaluation including MRI, cystourethroscopy, and several…
View details →Zehner KM, Salib A, Sanchez JG et al. · 2026 · Journal of hand surgery global online
Purpose Carpal tunnel syndrome may be considered for carpal tunnel injection (CTI). Ultrasound (US) guidance has been proposed to improve CTI accuracy, but the trend across the years, factors associated with utilization, and outcomes are…
View details →Almutairi M, Alalmaee R, Alamer E et al. · 2026 · Journal of clinical tuberculosis and other mycobacterial diseases
Background Tuberculosis (TB) is a major global health issue, particularly among HIV-positive individuals. In Saudi Arabia, the incidence has declined to 8.4 per 100,000 but remains a concern among high-risk groups. Extrapulmonary TB,…
View details →Zhang P, Guo Y, Xu Y et al. · 2025 · Talanta
The identification of natural active compounds is typically a cumbersome and time-intensive process due to the necessity for elaborate sample pretreatment, leading to inefficiencies. Although recent advancements have introduced methods for…
View details →Britnell JA, Palme R, Kerley GIH et al. · 2024 · Functional Ecology
Steroid hormones, especially glucocorticoids (GCs), are widely used to assess physiological responses to stressors. As steroid hormones are heavily metabolised prior to excretion, it is essential to validate enzyme immunoassays (EIAs) for…
View details →Anez SG, Flail DB, Burkhart EP et al. · 2025 · Journal of natural products
Monotropa uniflora L. ("ghost pipe"), is a North American traditional medicinal plant which has recently seen an increase in consumption nationwide. However, a single 1889 study reported the presence of grayanotoxin I in M. uniflora,…
View details →Strotzer QD, Nieberle F, Kupke LS et al. · 2024 · Radiology
Background Large language models have already demonstrated potential in medical text processing. GPT-4V, a large vision-language model from OpenAI, has shown potential for medical imaging, yet a quantitative analysis is lacking. Purpose To…
View details →Bäumges H, Jelinek S, Lange H et al. · 2025 · Cells
Fucose-containing glycoproteins and glycolipids broadly occur in humans as well as in many other species and are essential for a wide range of physiological processes, such as cell adhesion, fertilization, and tumor development. In humans,…
View details →Leslie WD, Zarzour F, Binkley N et al. · 2025 · Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Statins are among the most widely prescribed medications in older individuals. Inconsistent data in humans suggest that statin medications may be associated with greater BMD and lower risk for osteoporosis. We identified 22 393 individuals…
View details →Sadiq DR, Mikhael EM · 2024 · Clinical ophthalmology (Auckland, N.Z.)
Background Glaucoma is a chronic progressive eye disorder. It is the primary cause of blindness. To prevent glaucomatous damage and blindness, the intra-ocular pressure (IOP) must be lowered to certain levels, this level is known as "IOP"…
View details →Birk JB, Møller MA, Wojtaszewski JFP et al. · 2025 · FEBS letters
It has been proposed that the regulatory Sit4-associated protein subunit 3 (SAPS3) of protein phosphatase 6 (PP6C) acts as an AMP-activated protein kinase (AMPK) inhibitor by recruiting PP6C to dephosphorylate AMPKα-T172. While we confirm…
View details →Biçengil K, Kurt A, Naralan ME et al. · 2026 · Diagnostics (Basel, Switzerland)
Objectives : To evaluate the diagnostic performance of a YOLOv8x-based deep learning model for detecting approximal, occlusal and buccal caries on paediatric panoramic radiographs and to compare its performance with human observers with…
View details →Airaksinen J, Siimes S, Hartikainen J et al. · 2024 · Pflugers Archiv : European journal of physiology
Arrhythmia detection is essential when assessing the safety of novel drugs and therapies in preclinical studies. Many short-term arrhythmia monitoring methods exist, including non-invasive ECG and Holter. However, there are no reliable,…
View details →Ura H, Hatanaka H, Togi S et al. · 2025 · International journal of molecular sciences
RNA sequencing (RNA-Seq) is a powerful technique for the quantification of transcripts and the analysis of alternative splicing. Previously, our laboratory developed the targeted RNA long-amplicon sequencing (rLAS) method, which has the…
View details →Fan Z, Kitaura H, Marahleh A et al. · 2025 · International journal of molecular sciences
Bone remodeling is maintained through the coordinated actions of osteoblasts, osteoclasts, and osteocytes, among which osteocytes serve as major regulators of osteoclast-mediated bone resorption through the receptor activator of the…
View details →Stracquadanio S, Nicolosi A, Marino A et al. · 2024 · Diagnostics (Basel, Switzerland)
Background The rise of multi-drug-resistant Gram-negative bacteria necessitates the development of new antimicrobial agents. Cefiderocol shows promising activity by exploiting bacterial iron transport systems to penetrate the outer…
View details →Bui TI, Farnsworth CW, Anderson NW · 2024 · Journal of clinical microbiology
Many emergency departments (ED) use rapid human immunodeficiency virus (HIV) antibody tests as screening tools, despite limited sensitivity for detecting acute HIV infections. In a 4-year retrospective analysis of 1,192 patients, we…
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