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Browse the failure-mode index

11,312 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Negative / Null Result ReportMedicine

Complexities of Atrial Fibrosis Imaging: Exploring Relationships Between Endocardial Voltage, Extracellular Volume, and Sympathetic Innervation.

Wilk B, Lim H, Hicks J et al. · 2025 · JACC. Clinical electrophysiology

Background Atrial fibrillation is associated with abnormal synchronization of left atrial electrical activity and substantially increased risk of myocardial infarction, stroke and heart failure. Objectives This study sought to investigate,…

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Negative / Null Result ReportMedicine

Accuracy of artificial intelligence-based simulation for assessing lung vessels and volume using unenhanced computed tomography.

Fukuta K, Shimada Y, Nagamatu Y et al. · 2025 · European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery

Objectives The advantages of preoperative three-dimensional (3D) image simulations, which require enhanced computed tomography (ECT), for anatomical lung resection are well documented. However, the necessity for contrast agent presents a…

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Negative / Null Result ReportMedicine

Investigating disparity in labor epidural analgesia management in black vs. white women: a retrospective case-control study (2018-2022).

Clifton J, Woodward S, Hardcastle S et al. · 2025 · International journal of obstetric anesthesia

Background Disparities in labor epidural analgesia (LEA) management could reduce maternal satisfaction and increase risk. We compared times from the first administration of breakthrough pain medication (top-up) to LEA replacement to…

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Negative / Null Result ReportOpen accessMedicine

Skeletal muscle protein turnover and mitochondrial responses to omega-3 fatty acid supplementation: an update.

Hayden JE, Deane CS · 2026 · Current opinion in clinical nutrition and metabolic care

Purpose of review To critically review recent findings related to the effects of omega-3 fatty acid supplementation on skeletal muscle, with a particular focus on skeletal muscle protein turnover and mitochondrial function. Recent findings…

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Negative / Null Result ReportOpen accessMedicine

Video-Assisted Thoracoscopic Left Lower Lobectomy and Bronchial Foreign Body Removal for Treating a Rare Occult Bronchial Foreign Body in an Adult.

Shi Q, Bao J, Li J et al. · 2025 · Respirology case reports

Occult bronchial foreign bodies are extremely rare in adults. Affected patients typically lack a clear history of aspiration, exhibit no characteristic clinical signs and present with unremarkable chest imaging, often leading to…

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Negative / Null Result ReportOpen accessMedicine

Identifying a Critical Blind Spot: How Commercial AI (CAD) Systems Fail to Detect Faint Ground-Glass Opacities at -730 HU on Low-Dose CT.

Liang S, Wang J, Fu W et al. · 2026 · Diagnostics (Basel, Switzerland)

Objective: The integration of artificial intelligence (AI) into computer-aided detection (CAD) is a major innovation in lung cancer diagnosis. However, its reliability in detecting the earliest radiographic sign-faint ground-glass…

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Negative / Null Result ReportOpen accessMedicine

Sentinel Lymph Node Detection Using SPECT and Gamma Probe in Low-Risk Endometrial Cancer: Efficacy and Factors Associated With Detection Failure.

Asanoma K, Yahata H, Kodama K et al. · 2025 · Asian journal of endoscopic surgery

Introduction This study examined factors that affected sentinel lymph node (SLN) identification of patients with endometrial cancer having a preoperative estimation of low recurrent risk. Methods This study included 97 patients with…

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Negative / Null Result ReportMedicine

[Application of optical genome mapping technology for the detection of chromosomal structural variations].

Zhang Z, He S, Li X et al. · 2024 · Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics

Objective To assess the value of optical genome mapping (OGM) for the detection of chromosomal structural abnormalities including ring chromosomes, balanced translocations, and insertional translocations. Methods Clinical data of four…

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Negative / Null Result ReportOpen accessMedicine

Pipeline evaluation of a state-of-the-art AI algorithm for detection of focal cortical dysplasia: insights into potential failure sources.

Esmeraldo MA, Chambers S, Kravutske Y et al. · 2026 · Brain informatics

Purpose MELD Graph is a state-of-the-art artificial intelligence (AI) model for automated detection of focal cortical dysplasia (FCD), but its performance remains limited, highlighting the need to investigate which aspects of the pipeline…

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Negative / Null Result ReportMedicine

Evaluation of the AMP rapid test ROTA/ADENOVIRUS for simultaneous detection of rotavirus and adenovirus in stool samples.

Allahham M, Rennert W, Miller KM et al. · 2025 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Background Rotavirus (RV) and Adenovirus (AdV) gastroenteritis affect children worldwide. The sensitivity and specificity of the AMP Rapid Test ROTA/ADENOVIRUS [AMP-RA] for the detection of RV and AdV were compared against qPCR Allplex™…

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Negative / Null Result ReportMedicine

Twenty-one days of bed rest alter motor unit properties and neuromuscular junction transmission in young adults.

Sarto F, Kalc M, Motanova ES et al. · 2025 · Journal of applied physiology (Bethesda, Md. : 1985)

Previous studies showed that properties of higher-threshold motor units (MUs) and neuromuscular junction (NMJ) function are preserved during short-term disuse. This study aimed to test how a longer disuse period affects MU properties, NMJ…

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Negative / Null Result ReportOpen accessMedicine

Diagnostic Performance of Cardiac CT and Transthoracic Echocardiography in Congenital Heart Disease: A Surgical Correlation Study.

Bakhshaliyev S, Arslanoğlu E, Huseynov H et al. · 2026 · Diagnostics (Basel, Switzerland)

Background : This study evaluated the diagnostic efficacy of transthoracic echocardiography (TTE) and 128-slice multislice computed tomography (MSCT) angiography in congenital heart disease (CHD). Methods : Between January 2018 and August…

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Negative / Null Result ReportOpen accessMedicine

Reevaluating the senolytic activity of a GLS1 inhibitor and an anti-PD-1 antibody: toward greater reproducibility and methodological rigor.

Kawamoto S, Horiguchi H, Torigoe D et al. · 2026 · EMBO reports

The discovery of the senescence-associated secretory phenotype (SASP) has reshaped our understanding of cellular senescence, shifting its role from a solely tumor-suppressive mechanism to a potential driver of chronic inflammation and…

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Negative / Null Result ReportMedicine

Post-hoc out-of-distribution detection for cardiac MRI segmentation.

Arega TW, Bricq S, Meriaudeau F · 2025 · Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society

In real-world scenarios, medical image segmentation models encounter input images that may deviate from the training images in various ways. These differences can arise from changes in image scanners and acquisition protocols, or even the…

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Negative / Null Result ReportOpen accessMedicine

Establishing population-specific gestational weight gain ranges for twin pregnancies and comparing their performance with IOM recommendations: a retrospective cohort study from central China.

Yang R, Wang Y, Fu Q et al. · 2026 · BMJ open

Objectives To establish optimal pre-pregnancy body mass index (BMI)-specific gestational weight gain (GWG) ranges for twin pregnancies and compare their association with maternal and neonatal adverse outcomes against Institute of Medicine…

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Negative / Null Result ReportOpen accessMedicine

Measured and Estimated Glomerular Filtration Rate to Evaluate Rapid Progression and Changes over Time in Autosomal Polycystic Kidney Disease: Potential Impact on Therapeutic Decision-Making.

Miquel-Rodríguez R, González-Toledo B, Pérez-Gómez MV et al. · 2024 · International journal of molecular sciences

Autosomal polycystic kidney disease (ADPKD) is the most common genetic form of kidney failure, reflecting unmet needs in management. Prescription of the only approved treatment (tolvaptan) is limited to persons with rapidly progressing…

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