11,412 real negative results, null findings, and replication failures in Medicine · Negative / Null Result Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Wanner A · 2025 · BMJ open respiratory research
The airway wall is thickened in asthma and the airway microvasculature participates in the remodelling. It has been assumed but not convincingly demonstrated that the remodelled airway vasculature has a mechanical role in asthma-associated…
View details →Zhang X, Moran C, Wang R et al. · 2023 · Genes & genomics
Background According to the WHO, about 39% of the global adult population were overweight or obese in 2016. Obesity has high heritability, with more than 1000 variants so far identified. There have been reports indicating that salivary…
View details →Fiszdon JM, Wang K, Lê K et al. · 2024 · Schizophrenia research. Cognition
While cognitive remediation therapy (CRT) and compensatory strategy training both have large literature bases supporting their efficacy on both proximal and distal outcomes, the research base on stand-alone cognitive training (CT) is…
View details →Engoren M, Janda A, Heung M et al. · 2024 · Journal of cardiothoracic and vascular anesthesia
Objectives To estimate whether the association of transfusion and acute kidney injury (AKI) has a threshold of oxygen delivery below which transfusion is beneficial but above which it is harmful. Design Retrospective study SETTING:…
View details →El Sabagh A, Abdulraheem A, Jimenez A et al. · 2026 · JGH open : an open access journal of gastroenterology and hepatology
Background Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) improve glycemic control and promote weight loss but may increase gastric residue, raising concerns during esophagogastroduodenoscopy (EGD). African American patients remain…
View details →Piguet C, Celen Z, Meuleman B et al. · 2025 · Depression and anxiety
Adolescence is marked by major puberty-induced changes including increased reactivity to stress and a peak incidence of mental disorders. The implementation of early interventions during this developmental period is essential to prevent…
View details →Etuk REO, Forestell CA · 2021 · Appetite
Children often struggle to eat the daily recommended servings of fruits and vegetables, and as a result many have poor nutrient intake. This is especially problematic for neophobic children; or those who are hesitant to try new foods.…
View details →de Oliveira RMV, Vasques ACJ, Romero SA et al. · 2026 · European journal of clinical nutrition
Background Inflammatory Bowel Disease (IBD) involves genetic and environmental factors, but the relationship between disease activity, adiposity, and diet remains unclear. Objective To investigate the association between…
View details →Bekkai L, Ibn Majah A, Verset L et al. · 2025 · Diseases (Basel, Switzerland)
Background Olmesartan-induced enteropathy is a rare complication of a widely used angiotensin II receptor blocker. Patients usually present with chronic diarrhea and weight loss. Histologically, villous atrophy and intraepithelial…
View details →Desenzi R, Cuellar CJ, Hoorn QA et al. · 2025 · JDS communications
Pharmacological elevation of cyclic AMP (cAMP) of cultured cumulus-oocyte complexes (COC) before or coincident with initiation of maturation has been reported to improve outcomes for various systems for in vitro production of embryos. Here…
View details →Negen J · 2024 · PloS one
Bayesian reasoning (i.e. prior integration, cue combination, and loss minimization) has emerged as a prominent model for some kinds of human perception and cognition. The major theoretical issue is that we do not yet have a robust way to…
View details →Zhu Z, Feldman G · 2025 · Royal Society open science
Arkes (Arkes 1996 J. Behav. Decis. Mak. 9 , 213-224. (doi:10.1002/(SICI)1099-0771(199609)9:3 3.0.CO;2-1) demonstrated a phenomenon of wastefulness avoidance, showing that people's decisions are impacted by wastefulness, making decisions…
View details →von Spreckelsen P, Wessel I, Glashouwer KA et al. · 2023 · Memory (Hove, England)
People with a negative body image may be more likely to recall negative memories of their body, but also be motivated to avoid retrieving specific memories to prevent triggering aversive emotions (e.g., disgust). Such inclination to retain…
View details →Abu-Saif RA, Al-Basha AS, Al-Younes HM · 2023 · Enfermedades infecciosas y microbiologia clinica (English ed.)
Introduction Simkania negevensis has been linked to some respiratory and non-respiratory diseases. However, there is still a serious lack of clinical investigations that attempt to determine possible body sites that could be inhabited by…
View details →Jin X, Wang J, Du YJ et al. · 2026 · Medicine
Epidemiological evidence suggests that there is an association between systemic lupus erythematosus (SLE), type 1 diabetes (T1D), ankylosing spondylitis (AS), celiac disease (CD), and cognitive impairment (CI). However, the causal…
View details →Fahimi Z, Kazemi M, Rahimi H et al. · 2025 · IBRO neuroscience reports
Background Post-stroke epilepsy (PSE) is a significant complication in stroke survivors, yet early diagnostic biomarkers remain unclear. This study investigated whether circulating microRNA-219 (miR-219) could serve as a reliable biomarker…
View details →Rosoff DB, Bell AS, Wagner J et al. · 2024 · Cellular and molecular gastroenterology and hepatology
Background & aims Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse liver outcomes; however, liver disease incidence varies across…
View details →Kube T, Herzog P · 2023 · Journal of clinical psychology
Background Recent research suggests that dysfunctional expectations are a particularly important subtype of cognitions in depression. However, it is unclear whether depressive symptoms are related to the presence of negative expectations,…
View details →Xie H, Ratner K, Estevez M et al. · 2026 · Journal of research on adolescence : the official journal of the Society for Research on Adolescence
The Claremont Purpose Scale (CPS) was designed to assess youth purpose, but the English version has not yet undergone rigorous psychometric evaluation among adolescents. Prior validation efforts have also mostly relied on white-majority…
View details →Guerrero-Aranda A, Enríquez-Zaragoza A, López-Jiménez K et al. · 2024 · Clinical EEG and neuroscience
Background. Sleep is an activation procedure and is considered the most potent and best-documented modulator of seizures and interictal epileptiform discharges (IEDs) on electroencephalogram (EEG). The precise role of sleep deprivation in…
View details →Fasha TA, Rajuddin R, Dewi TP et al. · 2026 · Narra J
Endometriosis affects approximately 10% of women of reproductive age and is characterized by the presence of endometrial tissue outside the uterine cavity. Diagnostic delays are common due to nonspecific symptoms and the absence of…
View details →Liu Y, Zhang H · 2025 · Medicine
This study aimed to investigate the bidirectional causal relationship between celiac disease (CD) and the risk of Alzheimer disease (AD) or frontotemporal dementia (FTD) using Mendelian randomization (MR), in order to clarify prior…
View details →Jozefowiez J, Huff AG, Petruzzo L et al. · 2026 · Journal of experimental psychology. Animal learning and cognition
The expression of an association between a conditioned stimulus (CS) and an aversive unconditioned stimulus (US) can be weakened by presenting the CS by itself (extinction [Ext]), pairing it with an appetitive US (counterconditioning…
View details →Ochal M, Lewczuk KG, Dragańska E et al. · 2026 · Scientific reports
Low back pain (LBP) is one of the most prevalent musculoskeletal complaints and a leading cause of disability worldwide. Although patients frequently attribute symptom exacerbation to adverse weather, the scientific evidence for a direct…
View details →Wilson PR, Bridges KH, Scofield M et al. · 2024 · Pain management
Nonopioid analgesics serve to improve analgesia and limit side effects and risks of perioperative opioids. N-acetylcysteine (NAC), the primary treatment of acetaminophen toxicity, may have perioperative indications, including analgesia.…
View details →Wendler M, Leister D, Kleine T · 2026 · The New phytologist
Plastid-to-nucleus retrograde signaling coordinates nuclear gene expression with the developmental and physiological state of plastids. GENOMES UNCOUPLED 1 (GUN1), a chloroplast-localized PPR-SMR protein, remains a central yet poorly…
View details →Gottfried JA, Shen C, Morgan D et al. · 2026 · Optics express
In a previous publication [Opt. Express21, 28182 (2013)10.1364/OE.21.028182], Daido et al . reported that solid samples of metallic sodium exhibited high transparency of vacuum ultraviolet light through several millimeter-thick samples.…
View details →Weber S, Kemp SA, Hinder MR · 2026 · Cognitive, affective & behavioral neuroscience
Action cancellation represents a fundamental aspect of human motor control. Nonetheless, the behavioural paradigms used to study it are methodologically diverse and capture an incompletely understood combination of processes. Advancing…
View details →Wladis EJ, Aakalu VK, Dagi Glass LR et al. · 2026 · Ophthalmology
Objective To review the literature on the benefits and risks of systemic corticosteroids in the setting of orbital cellulitis. Methods A literature search was last performed in the PubMed database in August 2025. Articles were limited to…
View details →Benyoucef R, Goubet M, Barrat A et al. · 2026 · European radiology
Objectives External validation of six radiomic models published in three studies: two distinguishing benign from malignant lesions (study 1) and four distinguishing pleomorphic adenomas from Warthin's tumors (studies 2 and 3). Materials…
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