Browse the failure-mode index

4 real negative results, null findings, and replication failures in Immunology and Microbiology · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessImmunology and Microbiology

Tumor-secreted Pros1 inhibits macrophage M1 polarization to reduce antitumor immune response

Eric Ubil, Laura S. Caskey, Alisha Holtzhausen et al. · 2018 · Journal of Clinical Investigation

Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In…

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Failed Experiment ReportOpen accessImmunology and Microbiology

Radiation-induced circulating myeloid-derived suppressor cells induce systemic lymphopenia after chemoradiotherapy in patients with glioblastoma

Subhajit Ghosh, Jiayi Huang, Matthew Inkman et al. · 2023 · Science Translational Medicine

Severe and prolonged lymphopenia frequently occurs in patients with glioblastoma after standard chemoradiotherapy and has been associated with worse survival, but its underlying biological mechanism is not well understood. To address this,…

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Failed Experiment ReportOpen accessImmunology and Microbiology

Adjuvant MUC vaccination with tecemotide after resection of colorectal liver metastases: a randomized, double-blind, placebo-controlled, multicenter AIO phase II trial (LICC)

Carl Christoph Schimanski, Stefan Kasper, Susanna Hegewisch‐Becker et al. · 2020 · OncoImmunology

= .2141), respectively. Cox regression models revealed no dependence of RFS or OS on MUC1 expression. The most common tecemotide-related grade 3/4 adverse events were diarrhea, injection site reaction, intestinal perforation, peritonitis…

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Failed Experiment ReportOpen accessImmunology and Microbiology

Retargeting Oncolytic Vesicular Stomatitis Virus to Human T-Cell Lymphotropic Virus Type 1-Associated Adult T-Cell Leukemia

Dillon M. Betancourt, Juan Carlos Ramos, Glen N. Barber · 2015 · Journal of Virology

UNLABELLED: Adult T cell leukemia/lymphoma (ATL) is an aggressive cancer of CD4/CD25(+) T lymphocytes, the etiological agent of which is human T-cell lymphotropic virus type 1 (HTLV-1). ATL is highly refractory to current therapies, making…

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