Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Ramon Casanova, Sudhir Varma, Brittany Simpson et al. · 2016 · Alzheimer s & Dementia
INTRODUCTION: Recently, quantitative metabolomics identified a panel of 10 plasma lipids that were highly predictive of conversion to Alzheimer's disease (AD) in cognitively normal older individuals (n = 28, area under the curve [AUC] =…
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Cameron D. Palmer, Itsik Pe’er · 2017 · PLoS Genetics
Genome-wide association studies (GWAS) have identified hundreds of SNPs responsible for variation in human quantitative traits. However, genome-wide-significant associations often fail to replicate across independent cohorts, in apparent inconsistency with their apparent strong effects in discovery cohorts. This limited success of replication raises pervasive questions about the utility of the GWAS field. We identify all 332 studies of quantitative traits from the NHGRI-EBI GWAS Database with attempted replication. We find that the majority of studies provide insufficient data to evaluate repl
View details →Replication FailureOpen accessBiochemistry, Genetics and Molecular Biology
Karlijn Meeks, Peter Henneman, Andrea Venema et al. · 2017 · Clinical Epigenetics
Epigenome-wide association studies (EWAS) have identified DNA methylation loci involved in adiposity. However, EWAS on adiposity in sub-Saharan Africans are lacking despite the high burden of adiposity among African populations. We undertook an EWAS for anthropometric indices of adiposity among Ghanaians aiming to identify DNA methylation loci that are significantly associated. The Illumina 450k DNA methylation array was used to profile DNA methylation in whole blood samples of 547 Ghanaians from the Research on Obesity and Diabetes among African Migrants (RODAM) study. Differentially methylat
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Delilah Zabaneh, Eva Krapohl, Héléna A. Gaspar et al. · 2017 · Molecular Psychiatry
We used a case-control genome-wide association (GWA) design with cases consisting of 1238 individuals from the top 0.0003 (~170 mean IQ) of the population distribution of intelligence and 8172 unselected population-based controls. The…
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Kyle M. Walsh, Erik L. Anderson, Helen M. Hansen et al. · 2012 · Genetic Epidemiology
Genomewide association studies (GWAS) and candidate-gene studies have implicated single-nucleotide polymorphisms (SNPs) in at least 45 different genes as putative glioma risk factors. Attempts to validate these associations have yielded…
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Serena Porcari, Chiara CICCARESE, Vitor Heidrich et al. · 2026 · Nature Medicine
Renal cell carcinoma (RCC) is a common malignancy with limited durable responses to first-line immune checkpoint inhibitor (ICI)-based therapies. Emerging evidence implicates the gut microbiome in modulating ICI efficacy. In the…
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Jérôme Paul, Michel Verleysen, Pierre Dupont · 2013
Abstract. Embedded feature selection can be performed by analyzing the variables used in a Random Forest. Such a multivariate selection takes into account the interactions between variables but is not easy to interpret in a statistical…
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Dennis Poel, Elske C. Gootjes, Lotte Bakkerus et al. · 2020 · Cancer Medicine
BACKGROUND: Palliative systemic therapy is currently standard of care for patients with extensive metastatic colorectal cancer (mCRC). A biomarker predicting chemotherapy benefit which prevents toxicity from ineffective treatment is urgently needed. Therefore, a previously developed tissue-derived microRNA profile to predict clinical benefit from chemotherapy was evaluated in tissue biopsies and serum from patients with mCRC. METHODS: Samples were prospectively collected from patients (N = 132) who were treated with capecitabine or 5-FU/LV with oxaliplatin ± bevacizumab. Response evaluation wa
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