Extension of Fisher’s least significant difference method to multi-armed group-sequential response-adaptive designs
Wenyu Liu; D Stephen Coad · 2025 · Statistical Methods in Medical Research
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract (excerpt)
Multi-armed multi-stage designs evaluate experimental treatments using a control arm at interim analyses. Incorporating response-adaptive randomisation in these designs allows early stopping, faster treatment selection and more patients to…
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Metadata source: Crossref · DOI 10.1177/09622802251319896