Effects of intravenous administration of peripheral blood‐derived mesenchymal stromal cells after infusion of lipopolysaccharide in horses
Sandra D. Taylor; Priscila B. S. Serpa; Andrea P. Santos; Kelsey A. Hart; Sarah A. Vaughn; George E. Moore; Abhijit Mukhopadhyay; Allen E. Page · 2022 · Journal of Veterinary Internal Medicine
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Abstract Background A systemic and dysregulated immune response to infection contributes to morbidity and mortality associated with sepsis. Peripheral blood‐derived mesenchymal stromal cells (PB‐MSC) mitigate inflammation in animal models of sepsis. Allogeneic PB‐MSC administered IV to horses is well‐tolerated but therapeutic benefits are unknown. Hypothesis After IV lipopolysaccharide (LPS) infusion, horses treated with PB‐MSC would have less severe clinical signs, clinicopathological abnormalities, inflammatory cytokine gene expression, and oxidative stress compared to controls administered
Abstract by Sandra D. Taylor; Priscila B. S. Serpa; Andrea P. Santos; Kelsey A. Hart; Sarah A. Vaughn; George E. Moore; Abhijit Mukhopadhyay; Allen E. Page, Journal of Veterinary Internal Medicine (2022) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1111/jvim.16447