Cytotoxicity studies of Fe3O4 nanoparticles in chicken macrophage cells
Shan Zhang; Shu Wu; Yiru Shen; Yunqi Xiao; Lizeng Gao; Shourong Shi · 2020 · Royal Society Open Science
WASTE classifies this as Negative / Null Result Report · AI classification, approximate
The study found no significant effect — useful as a negative control or null benchmark for your own design.
Abstract
Magnetic Fe3O4 nanoparticles (Fe3O4-NPs) have been widely investigated for their biomedical applications. The main purpose of this study was to evaluate the cytotoxic effects of different sizes of Fe3O4-NPs in chicken macrophage cells (HD11). Experimental groups based on three sizes of Fe3O4-NPs (60, 120 and 250 nm) were created, and the Fe3O4-NPs were added to the cells at different doses according to the experimental group. The cell activity, oxidative index (malondialdehyde (MDA), superoxide dismutase (SOD) and reactive oxygen species (ROS)), apoptosis and pro-inflammatory cytokine secretio
Abstract by Shan Zhang; Shu Wu; Yiru Shen; Yunqi Xiao; Lizeng Gao; Shourong Shi, Royal Society Open Science (2020) — licensed CC BY 4.0.
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Metadata source: DOAJ · DOI 10.1098/rsos.191561