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6 real negative results, null findings, and replication failures in Neuroscience · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportNeuroscience

Gene delivery of neurturin to putamen and substantia nigra in Parkinson disease: A double‐blind, randomized, controlled trial

C. Warren Olanow, Raymond T. Bartus, Tiffany Baumann et al. · 2015 · Annals of Neurology

OBJECTIVE: A 12-month double-blind sham-surgery-controlled trial assessing adeno-associated virus type 2 (AAV2)-neurturin injected into the putamen bilaterally failed to meet its primary endpoint, but showed positive results for the…

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Failed Experiment ReportOpen accessNeuroscience

Quantifying Neural Oscillatory Synchronization: A Comparison between Spectral Coherence and Phase-Locking Value Approaches

Eric Lowet, Mark Roberts, Pietro Bonizzi et al. · 2016 · PLoS ONE

Synchronization or phase-locking between oscillating neuronal groups is considered to be important for coordination of information among cortical networks. Spectral coherence is a commonly used approach to quantify phase locking between neural signals. We systematically explored the validity of spectral coherence measures for quantifying synchronization among neural oscillators. To that aim, we simulated coupled oscillatory signals that exhibited synchronization dynamics using an abstract phase-oscillator model as well as interacting gamma-generating spiking neural networks. We found that, wit

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Failed Experiment ReportOpen accessNeuroscience

Melatonin: a possible link between the presence of artificial light at night and reductions in biological fitness

Therésa M. Jones, Joanna Durrant, Ellie B. Michaelides et al. · 2015 · Philosophical Transactions of the Royal Society B Biological Sciences

The mechanisms underpinning the ecological impacts of the presence of artificial night lighting remain elusive. One suspected underlying cause is that the presence of light at night (LAN) supresses nocturnal production of melatonin, a key…

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Failed Experiment ReportOpen accessNeuroscience

The Reference of Proper Names: Testing Usage and Intuitions

Michael Devitt, Nicolas Porot · 2018 · Cognitive Science

Experiments on theories of reference have mostly tested referential intuitions. We think that experiments should rather be testing linguistic usage. Substantive Aim (I): to test classical description theories of proper names against usage…

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Failed Experiment ReportOpen accessNeuroscience

Microglia-derived nanovesicles synchronize macroautophagy and chaperone-mediated autophagy for Alzheimer’s disease therapy

Min Li, Min Li, Shuang Chen et al. · 2025 · Signal Transduction and Targeted Therapy

Dysregulated autophagy is a hallmark of Alzheimer's disease (AD), yet the extent of impairment in macroautophagy and chaperone-mediated autophagy (CMA) remains unclear. Here, we show that both pathways are disrupted in AD model mice, preceding β-amyloid accumulation and driving disease progression. However, therapeutic autophagy modulation is severely restricted by the blood-brain barrier (BBB). To overcome this, we developed Microglia-Liposome Fusion Extrusion (MiLi-FE), a method to engineer microglia-derived nanovesicles (AR@ENV) for the codelivery of AR7 (a CMA inducer) and rapamycin (a mac

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