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490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportOpen accessMedicine

A biomechanical investigation comparing a novel bone cement bridging screw system with conventional treatment methods for Kummell’s disease

Yi Zhan, Huiming Yang, Jiangtao Wang et al. · 2024 · Scientific Reports

Abstract Based on the characteristics of Kummell’s disease (KD) and related anatomical structures of the thoracolumbar spine, a novel bone cement screw system has been designed to effectively avoid the cement loosening and displacement. This experiment aimed to assess the biological effects of the novel bone cement screw system in KD on fresh cadaveric thoracolumbar spine specimens, thereby discussing its potential application value and providing a foundation for clinical implementation. This study employed a total of 50 fresh female adult cadaver specimens. Each specimen underwent extraction

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Failed Experiment ReportMedicine

Effect of cross-head speed on the bond strength of dental resin to tooth structure - A review and re-analysis.

Hassan Elnadif H, Darvell BW · 2024 · Dental materials : official publication of the Academy of Dental Materials

Objective To review the published evidence for the role of cross-head speed on the apparent mechanical properties and bond strength of filled resins to tooth structure in order to identify the causes of inconsistency and contradictory…

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Failed Experiment ReportOpen accessMedicine

Efficacy of a novel combination of aloe vera gel and pineapple extracts in improving post-extraction pain and healing: A Randomized Controlled Trial.

Srivastava S, Kharkar VR, More S et al. · 2024 · Journal of clinical and experimental dentistry

Background Absorbable gelatin sponges are able to reduce the incidence of post-extraction complications when soaked with antimicrobial agents. However, the drawbacks associated with the injudicious use of antibiotics warrant the need to…

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Failed Experiment ReportMedicine

Embryo developmental and morphokinetic patterns in the domestic cat (Felis catus): associations with maternal age and SRT1720 supplementation during oocyte in vitro maturation.

Meco M, Carreira RP, Ochota M et al. · 2026 · Theriogenology

This study describes embryo developmental progression and morphokinetic patterns in embryos derived from oocytes of young and aged domestic cats, a model for endangered felids, using a time-lapse monitoring system. Because maternal aging…

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Failed Experiment ReportMedicine

Untargeted and targeted fortified balanced energy-protein (BEP) dietary supplementation during pregnancy and birth outcomes: a cluster-randomised effectiveness trial in rural Bangladesh.

Christian P, Ali H, Zavala E et al. · 2026 · BMJ global health

Antenatal balanced energy-protein (BEP) dietary supplementation is a WHO recommendation in undernourished settings, but limited evidence exists on targeting individuals based on nutritional status. We assessed the impact of untargeted and…

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Failed Experiment ReportMedicine

Plate configuration in midshaft clavicle fractures: influence of working length, screw number, and plate length-a retrospective cohort study of 355 patients.

Hinkelmann MA, Schibler D, Frei F et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

INTRODUCTION: Midshaft clavicle fractures are commonly treated with plate fixation; however, the selected plate working length varies widely. Biomechanical principles suggest potential effects on fracture healing, but clinical evidence…

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Failed Experiment ReportOpen accessMedicine

Relationship Between the Size-Frequency Distribution of Nucleopolyhedrovirus Occlusion Bodies and Their Insecticidal Characteristics on <i>Spodoptera frugiperda</i> (Lepidoptera: Noctuidae).

Ángel-García C, Lasa R, López-Meza JE et al. · 2026 · Viruses

The Spodoptera frugiperda multiple nucleopolyhedrovirus (SfMNPV) is an important pathogen of the fall armyworm and is used as the basis for biological insecticides. In this study, we examined the relationship between the size-frequency…

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Failed Experiment ReportMedicine

Retrospective assessment of low-dose and low-contrast agent protocols for photon-counting CT angiography of the aorta.

Hennes JL, Krompaß K, Huflage H et al. · 2026 · The international journal of cardiovascular imaging

Our objective was to assess dedicated low-dose (LD) and low-contrast (LC) scan protocols for aortic angiography, compared to standard protocols in photon-counting CT (PCD-CT) and energy-integrating CT (EID-CT). 57 patients (23 women) who…

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Failed Experiment ReportMedicine

Foraging crumbles reduce severe aggression in laboratory mice.

Bennett MB, Booth AB, Murdoch EQ et al. · 2026 · Physiology & behavior

Providing foraging crumbles in mouse cages is one method used in efforts to reduce aggression in laboratory mice. However, no studies have yet examined the effects of this procedure. Therefore, we investigated whether foraging crumbles…

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Failed Experiment ReportMedicine

Urinary dipstick findings and UTI risk with SGLT2 inhibitors: a post hoc analysis of the CANVAS and CREDENCE trials.

Doi Y, Hamano T, Fukuda-Doi M et al. · 2026 · Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

Background and hypothesis Despite established cardiorenal benefits, concerns about urinary tract infection (UTI) risk may limit SGLT2 inhibitor use, especially in high-risk patients. We hypothesized that urine leukocyte esterase (LE) and…

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Failed Experiment ReportMedicine

The risk of cerebrospinal fluid rhinorrhea from early resumption of positive pressure ventilation after transsphenoidal surgery with autologous fat graft repair.

Kim LJ, Rennert RC, Couldwell WT · 2026 · Journal of neurosurgery

Objective Multiple closure techniques may prevent CSF leak after transsphenoidal surgery for sellar lesions. In patients with obstructive sleep apnea requiring positive pressure ventilation (PPV), the optimal closure technique remains…

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Failed Experiment ReportOpen accessMedicine

The impact of infertility-related stress, physiological stress and some fertility indices on clinical pregnancy in women undergoing in vitro fertilization.

Omidifar N, Najafi E, Nasiri K et al. · 2025 · BMC pregnancy and childbirth

BACKGROUND: Despite numerous studies on the impact of stress on post-in vitro fertilization (IVF) clinical outcomes are contradictory and researchers recommend the need for further studies. Therefore, the purpose of the present study was…

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Failed Experiment ReportMedicine

Pre-post implementation study of a medication-focused order set for management of acute agitation in a pediatric emergency department.

Mills KP, Kemper M, Hoganson GM et al. · 2026 · American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists

Purpose To assess changes in prescribing practice after implementation of a medication-focused order set for acute agitation management in a pediatric emergency department (ED). Methods Patients 5 to 18 years of age who presented to the…

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Failed Experiment ReportMedicine

Field evaluation in the Eastern United States of a biological control Blossom Protect for fire blight suppression efficacy, potential to cause fruit russeting, and compatibility with fungicides.

Zeng Q, Cox K, Jung J et al. · 2026 · Plant disease

Fire blight is a destructive disease of apple and pear, and its severity is intensified under humid conditions. Biological controls are important components of the integrated management of plant diseases; however, field trials in the…

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Failed Experiment ReportOpen accessMedicine

An Exploratory Retrospective Study on the Association of Radiotherapy with the Risk of Immune-Related Adverse Events in Esophageal and Esophagogastric Junction Cancer Patients Receiving Immunotherapy.

Hokamura N, Fukagawa T, Fukushima R et al. · 2025 · Cancers

Background Radiotherapy (RT) combined with immune checkpoint inhibitors (ICIs) has shown therapeutic benefits, and the potential for enhanced immune activation has raised concerns about increased immune-related adverse events (irAEs). The…

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Failed Experiment ReportOpen accessMedicine

Caesarean myomectomy in Kano northern Nigeria

Omole-ohonsi A, Ashimi AO · 2008 · Ibom Medical Journal

Objective: To evaluate the feasibility and outcome of caesarean myomectomy. Patients and Methods: A retrospective study of cases of caesarean myomectomy at the Aminu Kano Teaching Hospital, Kano, Nigeria, a tertiary health facility in a developing country between January 1998 and December 2004. Outcome Measures: Age and parity of the women, number, size and location of fibroids, duration of operation, estimated blood loss, postoperative complications and duration of hospital stay. Results: Sixteen cases of caesarean myomectomy were done during the study period using the tourniquet method. It i

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