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490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

YTHDF proteins differentially regulate a subset of m6A-modified transcripts to restrain endothelial inflammation during homeostasis.

Shyam Kumar R, Chakraborty S, Jayakumar H et al. · 2026 · Molecular biology reports

Background N6-methyladenosine (m6A) modification of mRNAs through METTL3 maintains homeostasis in many cell types. The mechanism by which METTL3 complexes together with reader proteins, especially the YTH domain-containing protein, governs…

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Failed Experiment ReportOpen accessMedicine

The prognostic value of the Oocyte Maturation Index (OMI) on pregnancy outcomes in POSEIDON group 3 and 4 patients: a retrospective cohort study.

Bayram Y, Yildiz H, Ulger G et al. · 2026 · Journal of ovarian research

Background This study METHODS: A total of 662 patients treated at the Assisted Reproductive Techniques Unit of Mersin University Faculty of Medicine between 2016 and 2024 (Group 3: n=245; Group 4: n=417) were retrospectively analyzed.…

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Failed Experiment ReportMedicine

Survival outcomes of rectal and head and neck cancer patients receiving radio(chemo)therapy with a ketogenic diet. A post-hoc analysis from the KETOCOMP trial.

Klement RJ, Sweeney RA · 2026 · Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]

Purpose Ketogenic diets (KDs) have been proposed to target glycolytic cancer metabolism and synergize with radio- and chemotherapy. We herein report survival outcomes of rectal and head and neck cancer (HNC) patients who followed a KD…

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Failed Experiment ReportMedicine

Aztreonam plus ceftazidime/avibactam broth disk elution test: failure to detect Escherichia coli with PBP-3 insertions.

Peirano G, Walker SD, Duong MS et al. · 2026 · European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Introduction Metallo-β-lactamase (MBL)-producing Enterobacterales are increasing in frequency and treatment options are limited. Aztreonam/avibactam (AZA) and aztreonam (ATM) plus ceftazidime/avibactam (CZA) showed activities against these…

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Failed Experiment ReportMedicine

The agony of choice: Advancing sediment hazard assessment by using avoidance behaviour assays with Lumbriculus variegatus.

Hilgendorf J, Calisto V, Cardoso DN et al. · 2025 · Environmental toxicology and pharmacology

Sediments play a key role in chemical partitioning in aquatic ecosystems, acting as sinks for lipophilic and persistent compounds. However, sediment hazard assessment is limited, often underestimating risks by focusing on short-term,…

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Failed Experiment ReportOpen accessMedicine

A biomechanical investigation comparing a novel bone cement bridging screw system with conventional treatment methods for Kummell’s disease

Yi Zhan, Huiming Yang, Jiangtao Wang et al. · 2024 · Scientific Reports

Abstract Based on the characteristics of Kummell’s disease (KD) and related anatomical structures of the thoracolumbar spine, a novel bone cement screw system has been designed to effectively avoid the cement loosening and displacement. This experiment aimed to assess the biological effects of the novel bone cement screw system in KD on fresh cadaveric thoracolumbar spine specimens, thereby discussing its potential application value and providing a foundation for clinical implementation. This study employed a total of 50 fresh female adult cadaver specimens. Each specimen underwent extraction

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Failed Experiment ReportMedicine

Plate configuration in midshaft clavicle fractures: influence of working length, screw number, and plate length-a retrospective cohort study of 355 patients.

Hinkelmann MA, Schibler D, Frei F et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

INTRODUCTION: Midshaft clavicle fractures are commonly treated with plate fixation; however, the selected plate working length varies widely. Biomechanical principles suggest potential effects on fracture healing, but clinical evidence…

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Failed Experiment ReportOpen accessMedicine

Domain-specific cognitive screening in acute first-ever stroke: a comparative study of the Oxford Cognitive Screen (OCS) and ACE-III.

Tanglay O, Jhunjhnuwala D, Huynh W · 2025 · Frontiers in human neuroscience

Introduction Post-stroke cognitive impairment (PSCI) is common and often under-recognized, particularly in the acute phase. Most cognitive screening tools provide only a global score, overlooking domain-specific deficits that influence…

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Failed Experiment ReportOpen accessMedicine

The effects of resistance exercise and leucine-enriched essential amino acid supplementation on muscle mass and physical function in post-gastrectomy patients: a pilot randomized controlled trial.

Sawada A, Yoneta K, Togashi E et al. · 2024 · Journal of physical therapy science

[Purpose] In gastric cancer patients, low muscle mass decreases overall survival and quality of life (QOL). Resistance exercise with leucine-enriched essential amino acid (LEAA) supplementation may prevent muscle mass loss. This study was…

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Failed Experiment ReportOpen accessMedicine

Case Report: A case of occult insulinoma localized by [<sup>18</sup>F] FB (ePEG12)12-exendin-4 positron emission tomography with negative findings of selective arterial calcium stimulation test.

Sakaki K, Murakami T, Fujimoto H et al. · 2025 · Frontiers in endocrinology

Background Insulinomas, the most common functional pancreatic neuroendocrine tumors, cause hypoglycemia due to excessive insulin production, leading to severe clinical symptoms like coma or death. Resection surgery is the major curative…

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Failed Experiment ReportOpen accessMedicine

The impact of infertility-related stress, physiological stress and some fertility indices on clinical pregnancy in women undergoing in vitro fertilization.

Omidifar N, Najafi E, Nasiri K et al. · 2025 · BMC pregnancy and childbirth

BACKGROUND: Despite numerous studies on the impact of stress on post-in vitro fertilization (IVF) clinical outcomes are contradictory and researchers recommend the need for further studies. Therefore, the purpose of the present study was…

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Failed Experiment ReportMedicine

Noninvasive Right Ventricular Myocardial Work by Pressure-Strain Loop: A New Perspective on Right Ventricular Function and Cardiac Resynchronization Therapy.

Tian F, Hu C, Liu W et al. · 2025 · The American journal of cardiology

Myocardial work (MW) by noninvasive pressure-strain loop (PSL) is a novel echocardiographic tool that provides a more precise estimation of right ventricular (RV) performance by accounting for the RV loading conditions. The study sought to…

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Failed Experiment ReportMedicine

Breaking the Rules: Upper Pole Ureteropelvic Junction Obstruction Causing Massive Urinary Tract Dilation in a Neonate With Prenatal Diagnosis of Multicystic Dysplastic Kidney.

Grant Owens R, Lockwood G, Storm D · 2025 · Urology

Prenatal diagnosis of left multicystic dysplastic kidney (MCDK) and ureterocele was made in a male fetus at 24-week gestation. The initial postnatal course was uneventful. At 4 weeks of age, he developed urosepsis and respiratory distress.…

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Failed Experiment ReportMedicine

Leukocoria in a 4-year-old boy.

Altamirano F, Gonzalez E, Oke I · 2024 · Digital journal of ophthalmology : DJO

A healthy 4-year-old boy referred for evaluation of an abnormal red reflex in the left eye was noted, on fundus examination, to have extensive white, striated lesions surrounding the optic nerve that involved the superior and inferior…

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Failed Experiment ReportOpen accessMedicine

Rumen-protected lysine and methionine failed to improve the performance of late-nursing Awassi ewes regardless of dietary protein contents.

Awawdeh MS · 2024 · Journal of advanced veterinary and animal research

Objective The current study investigated the effects of supplying ruminally protected amino acids (AA) (lysine, L; and methionine, M) and dietary protein levels on the performance of late-nursing ewes. Materials and methods Thirty-one…

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Failed Experiment ReportOpen accessMedicine

Caesarean myomectomy in Kano northern Nigeria

Omole-ohonsi A, Ashimi AO · 2008 · Ibom Medical Journal

Objective: To evaluate the feasibility and outcome of caesarean myomectomy. Patients and Methods: A retrospective study of cases of caesarean myomectomy at the Aminu Kano Teaching Hospital, Kano, Nigeria, a tertiary health facility in a developing country between January 1998 and December 2004. Outcome Measures: Age and parity of the women, number, size and location of fibroids, duration of operation, estimated blood loss, postoperative complications and duration of hospital stay. Results: Sixteen cases of caesarean myomectomy were done during the study period using the tourniquet method. It i

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