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490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →

WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.

Failed Experiment ReportMedicine

Two fluffy family proteins, CgrFlbA and CgrFlbC, coordinately regulate hyphal growth, oxidative stress, asexual development, and pathogenicity in Colletotrichum graminicola.

Lin S, Wei H, Guo C et al. · 2026 · Microbial pathogenesis

Colletotrichum graminicola, the causal agent of maize anthracnose, is responsible for substantial global crop losses. While the fluffy family proteins (FlbA-FlbE, FluG) are known as key upstream activators of asexual development in…

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Failed Experiment ReportMedicine

Impact of a home-based obesity prevention intervention on children's eating behaviours: Findings from the Guelph Family Health Study randomised controlled trial.

Jacob R, Walton K, Buchholz AC et al. · 2026 · Appetite

Children's eating behaviours are important determinants of childhood obesity; however, few studies have examined whether early childhood obesity prevention interventions influence these behaviours. This study investigated the impact of a…

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Failed Experiment ReportMedicine

The Impact of the Geriatric Emergency Department Initiative on Older Community Dwelling Adults Presenting to the Emergency Department With a Completed Delirium Screen.

Williams K, Craswell A, Tsao H et al. · 2026 · Emergency medicine Australasia : EMA

Objective Australia's ageing population resulted in increasing Emergency Department (ED) presentations among older adults, particularly frail and those at risk of adverse outcomes. Delirium contributes significantly to morbidity in this…

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Failed Experiment ReportOpen accessMedicine

Efficacy assessment of a novel endolysin PlyAZ3aT for the treatment of ceftriaxone-resistant pneumococcal meningitis in an infant rat model.

Luca G Valente, Ngoc Dung Le, Melissa Pitton et al. · 2022 · PLoS ONE

Background Treatment failure in pneumococcal meningitis due to antibiotic resistance is an increasing clinical challenge and alternatives to antibiotics warrant investigation. Phage-derived endolysins efficiently kill gram-positive bacteria including multi-drug resistant strains, making them attractive therapeutic candidates. The current study assessed the therapeutic potential of the novel endolysin PlyAZ3aT in an infant rat model of ceftriaxone-resistant pneumococcal meningitis. Methods Efficacy of PlyAZ3aT was assessed in a randomized, blinded and controlled experimental study in infant Wis

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Failed Experiment ReportMedicine

Failed air enema reduction leading to the diagnosis of small-bowel intussusception secondary to Meckel's diverticulum with ectopic gastric mucosa in a 5-month-old infant: A case report.

Wang, Yu · 2026 · SAGE open medical case reports

A 5-month-old infant presented with paroxysmal crying and vomiting for more than 4 h. Ultrasonography confirmed intussusception in the right abdomen, but intraluminal gas limited precise classification. On the assumption of…

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Failed Experiment ReportMedicine

Electroacupuncture ameliorates gastrointestinal motility and modulates PLC-IP3 signaling in a rat model of functional dyspepsia.

Yang D, Fang L, Chen Q et al. · 2025 · Acupuncture in medicine : journal of the British Medical Acupuncture Society

Objective The aim of this study was to determine whether electroacupuncture (EA) modulates the phospholipase C-inositol-1,4,5-trisphosphate (PLC-IP3) pathway and platelet-derived growth factor receptor (PDGFR)α + cells in a rat model of…

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Failed Experiment ReportMedicine

Clinical Outcomes of First-Line Immune Checkpoint Inhibitor-Based Therapy for Postoperative Recurrence After Adjuvant Nivolumab in Esophageal Cancer.

Sugase T, Kanemura T, Matsuura N et al. · 2026 · Annals of surgical oncology

Background Adjuvant nivolumab has become a standard treatment after curative resection for locally advanced esophageal cancer; however, postoperative recurrence remains common. The efficacy of immune checkpoint inhibitor (ICI)-based…

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Failed Experiment ReportOpen accessMedicine

Effects of ischemic conditioning on head and neck free flap oxygenation: a randomized controlled trial

Se-Hee Min, Suk Hyung Choe, Won Shik Kim et al. · 2022 · Scientific Reports

Abstract Flap failure after microvascular reconstructive surgery is a rare but devastating complication caused by reperfusion injury and tissue hypoperfusion. Remote ischemic conditioning (RIC) provides protection against ischemia/reperfusion injury and reduces tissue infarction. We hypothesized that RIC would enhance flap oxygenation and exert organ-protective effects during head and neck free flap reconstructive surgery. Adult patients undergoing free flap transfer surgery for head and neck cancer were randomized to receive either RIC or sham-RIC during surgery. RIC consisted of four cycles

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Failed Experiment ReportOpen accessMedicine

The prognostic value of the Oocyte Maturation Index (OMI) on pregnancy outcomes in POSEIDON group 3 and 4 patients: a retrospective cohort study.

Bayram Y, Yildiz H, Ulger G et al. · 2026 · Journal of ovarian research

Background This study METHODS: A total of 662 patients treated at the Assisted Reproductive Techniques Unit of Mersin University Faculty of Medicine between 2016 and 2024 (Group 3: n=245; Group 4: n=417) were retrospectively analyzed.…

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Failed Experiment ReportOpen accessMedicine

A biomechanical investigation comparing a novel bone cement bridging screw system with conventional treatment methods for Kummell’s disease

Yi Zhan, Huiming Yang, Jiangtao Wang et al. · 2024 · Scientific Reports

Abstract Based on the characteristics of Kummell’s disease (KD) and related anatomical structures of the thoracolumbar spine, a novel bone cement screw system has been designed to effectively avoid the cement loosening and displacement. This experiment aimed to assess the biological effects of the novel bone cement screw system in KD on fresh cadaveric thoracolumbar spine specimens, thereby discussing its potential application value and providing a foundation for clinical implementation. This study employed a total of 50 fresh female adult cadaver specimens. Each specimen underwent extraction

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Failed Experiment ReportMedicine

Efficacy of low dose colchicine on left ventricular hypertrophy in patients with coronary artery disease: A randomized controlled trial.

Chichareon P, Suwannanon R, Thungthienthong M et al. · 2026 · British journal of clinical pharmacology

Background Left ventricular hypertrophy (LVH) contributes to a substantial risk of adverse outcomes in patients with coronary artery disease (CAD). Inflammation is one of the mechanisms responsible for LVH progression. The study aimed to…

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Failed Experiment ReportMedicine

ALSUntangled #82: N-acetylcysteine.

Yerraguntla S, Bakshi B, Chandran K et al. · 2026 · Amyotrophic lateral sclerosis & frontotemporal degeneration

N-acetylcysteine is a thiol-containing compound and a precursor of glutathione, with mechanistic plausibility for ALS, including reducing oxidative stress, regulating neuroinflammation, and mitigating mitochondrial dysfunction. Preclinical…

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Failed Experiment ReportMedicine

Plate configuration in midshaft clavicle fractures: influence of working length, screw number, and plate length-a retrospective cohort study of 355 patients.

Hinkelmann MA, Schibler D, Frei F et al. · 2026 · European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

INTRODUCTION: Midshaft clavicle fractures are commonly treated with plate fixation; however, the selected plate working length varies widely. Biomechanical principles suggest potential effects on fracture healing, but clinical evidence…

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Failed Experiment ReportOpen accessMedicine

Demise of the Milwaukee Protocol for Rabies.

Jackson AC · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Human rabies has a very high fatality rate and there have only been about 34 well-documented survivors, defined as survival at 6 months after onset of clinical rabies. Many have had serious neurological sequelae. After a young patient…

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Failed Experiment ReportOpen accessMedicine

Diagnostic Challenges of LRP4 Antibody Testing in Myasthenia Gravis: A Case Series of Four LRP4 Positive Cases With Uncertain Diagnostic Significance.

Kinnard KR, Khalid E · 2026 · Case reports in neurological medicine

Myasthenia gravis is an autoimmune disorder characterized by muscle weakness due to impaired neuromuscular transmission. While antibodies against the acetylcholine receptor and muscle-specific kinase are commonly used for diagnosis, a…

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Failed Experiment ReportOpen accessMedicine

The impact of infertility-related stress, physiological stress and some fertility indices on clinical pregnancy in women undergoing in vitro fertilization.

Omidifar N, Najafi E, Nasiri K et al. · 2025 · BMC pregnancy and childbirth

BACKGROUND: Despite numerous studies on the impact of stress on post-in vitro fertilization (IVF) clinical outcomes are contradictory and researchers recommend the need for further studies. Therefore, the purpose of the present study was…

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Failed Experiment ReportOpen accessMedicine

Historical Perspective of HER2 Testing and Treatment in Prostate Cancer.

Zamalloa N, Rose J, Lap CJ et al. · 2026 · Current oncology (Toronto, Ont.)

Human epidermal growth factor receptor 2 (HER2) is a molecular target of interest in prostate cancer due to its association with poor prognosis and its potential role in androgen receptor signaling. However, earlier clinical trials…

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Failed Experiment ReportMedicine

Bladder region-specific analysis of the diagnostic performance of oral 5-aminolevulinic acid fluorescence cystoscopy in non-muscle-invasive bladder cancer.

Ishikawa Y, Tanaka H, Kobayashi M et al. · 2026 · Japanese journal of clinical oncology

Background Fluorescence cystoscopy (FL) using 5-aminolevulinic acid (ALA) enhances the detection of urothelial carcinoma compared to white-light endoscopy (WL). The location of bladder tumors may affect the diagnostic performance of FL;…

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Failed Experiment ReportOpen accessMedicine

Caesarean myomectomy in Kano northern Nigeria

Omole-ohonsi A, Ashimi AO · 2008 · Ibom Medical Journal

Objective: To evaluate the feasibility and outcome of caesarean myomectomy. Patients and Methods: A retrospective study of cases of caesarean myomectomy at the Aminu Kano Teaching Hospital, Kano, Nigeria, a tertiary health facility in a developing country between January 1998 and December 2004. Outcome Measures: Age and parity of the women, number, size and location of fibroids, duration of operation, estimated blood loss, postoperative complications and duration of hospital stay. Results: Sixteen cases of caesarean myomectomy were done during the study period using the tourniquet method. It i

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