83 real negative results, null findings, and replication failures in Medicine · Methods Dead-End. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Fiebig N, Bartsch L, Klötzer C et al. · 2026 · Headache
Objective To evaluate the effects of a short, structured multimodal day-clinic program on health-related quality of life and disability in patients with primary headache disorders. Background Although monoclonal antibodies targeting the…
View details →Jean J, Klein JI, Karashchuk N et al. · 2026 · Headache
Objective To determine if there is increased headache burden and disability among women with and without migraine during an in vitro fertilization (IVF) cycle. Background Migraine and infertility commonly impact women of childbearing age.…
View details →Yang H, Yang L, Li Z et al. · 2025 · Medicine
Observational studies have reported associations between coffee intake and osteoarthritis (OA), rheumatoid arthritis (RA), and osteoporosis (OP). However, it remains unknown whether these relationships are causal. In this study, we applied…
View details →Jiang Y, Zanganeh M, Waugh N et al. · 2026 · Gastrointestinal endoscopy
Background and aims Endoscopy units are increasingly being encouraged to consider replacing multiple-use (MU) endoscopes with single-use (SU) endoscopes, largely due to reduction in cross-infection. While evidence suggests comparable…
View details →Whitty JA, Wagner AP, Kang E et al. · 2023 · The Australian & New Zealand journal of obstetrics & gynaecology
Background There is growing evidence regarding the potential of closed incision negative pressure wound therapy (ci-NPWT) to prevent surgical site infections (SSIs) in healing wounds by primary closure following a caesarean section (CS).…
View details →Polak M, Wiatrzyk A, Krysztopa-Grzybowska K et al. · 2026 · Biosensors
The translation of nucleic acid amplification into practical point-of-care and biosensor-integrated diagnostics is still significantly impeded by the necessity for rapid sample preparation. For this reason, a broad comparison of seven…
View details →Sayeedi I, Goldin J, Widrich J · 2026
The methacholine challenge test is a bronchoprovocation test used to assess airway hyperresponsiveness and aid in the diagnosis of asthma. Methacholine, a derivative of acetylcholine, directly stimulates airway smooth muscle receptors,…
View details →Roschütz D, Stolzenburg JU, von Dercks N · 2025 · Urologie (Heidelberg, Germany)
Background The expansion of the AOP (ambulatory operation procedure) catalog according to § 115 b SGB V in the years 2023 and 2024, as well as the introduction of hybrid-DRGs (disease-related groups) according to § 115 f SGB V, poses…
View details →van Orten-Luiten ACB, Brouwer-Brolsma EM, Janse A et al. · 2025 · European journal of clinical pharmacology
Purpose Chronic hyponatremia in older people is associated with adverse outcomes including gait disturbances, falls, osteoporosis, fractures, cognitive impairment, and cardiovascular disease. Diagnosis in outpatient settings is challenging…
View details →Hamada S, Satomoto K, Goto K et al. · 2026 · Mutation research. Genetic toxicology and environmental mutagenesis
Objective The liver micronucleus (MN) assay is useful for detecting genotoxic hepatocarcinogens that may be missed by the erythrocyte MN assay. Because micronuclei form only in dividing cells, evaluating hepatocyte proliferation is…
View details →Candiago Júnior AF, Traebert J, Cordeiro EZ · 2025 · Revista do Colegio Brasileiro de Cirurgioes
Introduction Sentinel lymph node biopsy is fundamental for staging and prognostication of cutaneous melanoma when indicated. However, it still yields a high rate of negative results. To reduce the rate of true negatives, oncology centers…
View details →Some DY, Kiemde F, Kabore B et al. · 2026 · PloS one
Objective To evaluate the field accuracy of a malaria diagnostic algorithm combining sequential interpretation of two-step malaria RDT detecting PfHRP2 and pLDH with information on previous antimalarial treatments within the past four…
View details →de Andrade Filho PH, da Silva Souza Barbosa R, Tafner GP et al. · 2026 · Journal of clinical anesthesia
Background The pericapsular nerve group (PENG) block has emerged as an effective regional anesthesia technique for managing hip pain, offering substantial analgesia while preserving motor function. However, the minimum effective volume…
View details →Hirsch W, Enns EA, Khoruts A et al. · 2026 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background Fecal microbiota transplantation (FMT) is the cost-effective strategy for managing recurrent Clostridioides difficile infection (rCDI). Prior costing models assumed FMT administration via colonoscopy. With the commercialization…
View details →Chopra AA, MacLeod JS, Compton TM et al. · 2026 · Clinical spine surgery
Study design Break-even cost analysis. Objectives This study uses a break-even cost-effectiveness model to assess whether enoxaparin is cost-effective for venous thromboembolism (VTE) prophylaxis in patients undergoing posterior lumbar…
View details →Nduka IJ, Okafor CE, Ekwunife OI · 2026 · PloS one
Mammography still remains the gold standard for breast cancer screening, considering its impact on breast cancer mortality. However, it has a relatively low utilization rate in Nigeria. Although the National Strategic Cancer Control Plan…
View details →Jin L, Han L, Zeng J · 2026 · Frontiers in public health
Background For patients with advanced EGFR-mutant non-small cell lung cancer (NSCLC) who progress after first-line therapy, effective subsequent options are urgently needed. From the perspective of China's healthcare system, this study…
View details →Demnitz-King H, Cooper C, Poppe M et al. · 2026 · Age and ageing
Background Previous studies have modelled long-term cost-effectiveness of dementia prevention but seldom within trials. APPLE-Tree (Active Prevention in People at risk of dementia through Lifestyle, bEhaviour change and Technology to build…
View details →Ecertaş BM, Erdem NZ · 2026 · BMC public health
Sedentary work environments may contribute to unhealthy dietary behaviors and increase the risk of non-communicable diseases among white-collar employees.This cross-sectional study examined the diet quality and its associations with…
View details →Simão AC, de Oliveira MBG, Menezes Junior ADS · 2026 · Cardiology
Introduction This umbrella review aims to evaluate the certainty and consistency of the available evidence rather than to provide a new procedural comparison. We combined systematic reviews that looked at surgical septal myectomy (SM) and…
View details →Han LJ, Pan XW, Zhu J et al. · 2026 · Journal of multidisciplinary healthcare
Purpose Acute pancreatitis has complex causes, and traditional Chinese medicine plays a significant role in its treatment. However, there is a lack of standardized protocols and a comprehensive best evidence summary for rhubarb…
View details →Fontanier V, Delforge E, Opplert J et al. · 2026 · Physical therapy
Importance Evidence-based practice (EBP) is a core competency in physical therapy. In 2015, France implemented a major reform of physical therapist education, extending training from 3 to 5 years and embedding EBP throughout the…
View details →Maldonado M, Boedeker P, Kusnoor AV · 2026 · The clinical teacher
Background Management reasoning (MR), the component of clinical reasoning concerned with treatment planning, patient preferences and resource considerations, develops later than diagnostic reasoning and remains underemphasised in medical…
View details →Kanpittaya P, Nantanee R, Fakhruddin KS et al. · 2026 · International journal of oral and maxillofacial surgery
External apical root resorption (EARR) is a recognized adverse outcome of orthodontic treatment that may also be influenced by orthognathic surgery. However, the body of evidence on this combined effect is nascent and has not been mapped.…
View details →Zhu J, Li Z, Song D et al. · 2026 · BMC health services research
Background The IMforte trial had supported lurbinectedin as a recommended first-line maintenance therapy for patients with extensive-stage small-cell lung cancer (ES-SCLC), while its cost-effectiveness remains uncertain for patients and…
View details →Haslam A, Olivier T, Prasad V · 2023 · ESMO open
Background The statistical plan of a phase II trial should balance minimizing the premature termination of potentially beneficial therapies (i.e. false negatives) and the further, costly testing of ineffective drugs (i.e. false positives).…
View details →Andersen E, Bohler L, Leirbakk MJ et al. · 2025 · BMC public health
Background Given the elevated prevalence and impact of overweight and the potential risk of non-communicable diseases among women of Somali background in high-income countries and recognising the potential positive impact of physical…
View details →Khatib M, Robinson D, Lavon E et al. · 2026 · Journal of clinical medicine
Background/Objectives : Chronic lower limb ulcers represent a significant clinical challenge, with conventional therapies achieving healing in only 30-40% of complex cases. This study evaluated the comparative effectiveness of autologous…
View details →Schötz C, White A, Gelbrecht M et al. · 2026 · Chaos (Woodbury, N.Y.)
Predicting chaotic dynamical systems is critical in many scientific fields, such as weather forecasting, but challenging due to the characteristic sensitive dependence on initial conditions. Traditional modeling approaches require…
View details →Gurbaxani BM · 2026 · Epidemics
Objectives The COVID-19 pandemic highlighted the need for non-pharmaceutical interventions (NPI) to mitigate hospitalization and death prior to vaccine availability. However, the precise impact of those mitigations have remained…
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