490 real negative results, null findings, and replication failures in Medicine · Failed Experiment Report. Search the index →
WASTE indexes published research — it does not host or republish full papers. Each entry is a metadata record compiled from open scholarly databases; the abstract is shown in full only where the paper is openly licensed, otherwise a short excerpt under fair use. Classifications are automated and approximate.
Pope JE · 2020 · The Lancet. Rheumatology
Strides have been made in the treatment of pulmonary arterial hypertension and interstitial lung disease in patients with systemic sclerosis, with successful trials of combination therapies in pulmonary arterial hypertension and of new…
View details →Persu A, Stoenoiu MS, Maes F et al. · 2023 · Clinical kidney journal
Following second-generation randomized trials, there is evidence that renal denervation (RDN) decreases blood pressure (BP), although to a lesser extent than suggested in the initial controlled and observational studies. The recent…
View details →Azarbarzin A, Vena D, Esmaeili N et al. · 2026 · European heart journal
Background and aims Randomized trials of continuous positive airway pressure (CPAP) treatment for obstructive sleep apnoea (OSA) in patients with cardiovascular disease have not detected reduced risk of major adverse cardiovascular and…
View details →de Zeeuw D · 2020 · Journal of nephrology
Patients with type 2 diabetes run a high risk for progressive renal function loss. Many interventions have been tested to reduce the risk, but we are nowadays still confronted with a high unmet need. To improve on this unmet need, we will…
View details →Georgiadis AG, Schavee PE, Koester TM et al. · 2025 · JB & JS open access
Background Cast removal may produce pain or anxiety in children. Virtual reality (VR) has been studied in other pediatric settings, but little evidence exists for its use during pediatric cast removal. Methods A randomized controlled trial…
View details →Bromberg JEC, Issa S, van der Holt B et al. · 2024 · Neuro-oncology
Background Studies on the efficacy of rituximab in primary CNS lymphoma (PCNSL) reported conflicting results. Our international randomized phase 3 study showed that the addition of rituximab to high-dose methotrexate, BCNU, teniposide, and…
View details →Gomeni R, Hopkins S, Bressolle-Gomeni F et al. · 2023 · Translational psychiatry
The objective of this study was to evaluate the performances of the propensity score weighted (PSW) methodology in a post-hoc re-analysis of a failed and a negative RCTs in depressive disorders. The conventional study designs,…
View details →Arter ZL, Nagasaka M · 2024 · Lung Cancer (Auckland, N.Z.)
Targeted therapies, such as epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), have revolutionized the treatment landscape for EGFR-mutant non-small cell lung cancer (NSCLC). However, the emergence of resistance to…
View details →Chen H, Colasurdo M, Matsukawa H et al. · 2025 · European stroke journal
Introduction Endovascular thrombectomy (EVT) is an effective treatment for basilar artery occlusion (BAO) stroke in select patients. While there is a growing body of literature suggesting that advanced imaging modalities such as computed…
View details →Nickel JC, Moldwin R, Hanno P et al. · 2019 · The Journal of urology
Purpose In this 12-week, randomized, double-blind, placebo controlled, multicenter, 3-arm, parallel group, phase 3 trial we assessed the effects of a novel SHIP1 activator on bladder pain and urinary symptoms in patients with interstitial…
View details →Jansen D, Deleu S, Caenepeel C et al. · 2025 · Gut microbes
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent colonic inflammation. Standard treatments focus on controlling inflammation but remain ineffective for one-third of patients. This underscores the need for…
View details →Limon D, Amiel A, Even Haim S et al. · 2024 · Neuro-oncology advances
Background Atypical and anaplastic meningiomas account for 20% of all meningioma cases. Solitary fibrous tumor (SFT) is a type of soft tissue sarcoma with similar attributes to meningioma. For patients with refractory or recurrent disease…
View details →Bae-Jump VL, Sill MW, Gehrig PA et al. · 2025 · Gynecologic oncology
Introduction We evaluated the efficacy of the addition of the anti-diabetic drug metformin to standard-of-care paclitaxel and carboplatin (PC) in patients with advanced and recurrent endometrial cancer (EC). Methods In this phase II/III…
View details →Rosell R, Karachaliou N, Codony J et al. · 2014 · Translational lung cancer research
Designing molecular targeted therapy with high specificity based on novel tumor biomarkers is a high priority in lung cancer research. Several molecular aberrations have been already identified in non-small cell lung cancer (NSCLC), with…
View details →Ip EH, Saldana S, Miller KD et al. · 2021 · Cancer
Background E5103 was a study designed to evaluate the efficacy and safety of bevacizumab. It was a negative trial for the end points of invasive disease-free survival and overall survival. The current work examines the tolerability of…
View details →O'Sullivan Coyne G, Burotto M · 2014 · Expert opinion on biological therapy
Introduction Monoclonal antibodies and small molecules targeting the VEGF pathway are part of the arsenal to treat malignant tumors. Antiangiogenesis therapies has been studied in breast cancer with partial success, reflected by the…
View details →Jones SA, Morand EF · 2024 · Drugs
The development of new medicines for systemic lupus erythematosus (SLE) has not addressed unmet clinical need, with only three drugs receiving regulatory approval for SLE in the last 60 years, one of which was specifically licensed for…
View details →Saraceni F, Scortechini I, Mancini G et al. · 2021 · Transplant infectious disease : an official journal of the Transplantation Society
Graft-versus-host disease (GVHD) is a common complication of hematopoietic stem cell transplant, which is known to be mediated by cytotoxic T-cell effectors and dysregulated inflammatory cytokines. Similarly, the lung injury observed in…
View details →Scheperjans F, Levo R, Bosch B et al. · 2024 · JAMA neurology
Importance Dysbiosis has been robustly demonstrated in Parkinson disease (PD), and fecal microbiota transplantation (FMT) has shown promising effects in preclinical PD models. Objective To assess the safety and symptomatic efficacy of…
View details →Black PC, Tangen CM, Singh P et al. · 2023 · European urology
Background Although radical cystectomy (RC) is the standard of care for patients with bacillus Calmette-Guérin (BCG)-unresponsive high-risk non-muscle-invasive bladder cancer (NMIBC), many patients are ineligible for surgery or elect…
View details →Coxon AT, Johanns TM, Dunn GP · 2020 · Missouri medicine
Glioblastoma is a devastating disease with a dismal prognosis. While recent advancements in cancer immunotherapy have led to improvements in treating other types of cancer, patients with glioblastoma have not benefited from these new…
View details →Tripathy S, Acharya SP, Sahoo AK et al. · 2022 · Critical care explorations
Optimal time for ICU diary delivery and impact on mental health (MH), anxiety-depression, post-traumatic stress symptoms (PTSS), quality of life (QOL), and memories is unclear. We evaluated the effect of ICU diaries, dispatched at…
View details →Biscaglia S, Tebaldi M, Mele D et al. · 2019 · European heart journal supplements : journal of the European Society of Cardiology
Despite the evolution in pharmacology and devices, recurrent and persistent angina still represent a frequent issue in clinical practice. A 69-year-old Caucasian female patient has history of surgical aortic valve replacement with a…
View details →Hsu CT, Sato W · 2023 · Sensors (Basel, Switzerland)
Although electromyography (EMG) remains the standard, researchers have begun using automated facial action coding system (FACS) software to evaluate spontaneous facial mimicry despite the lack of evidence of its validity. Using the facial…
View details →Regan JJ, Wang Z, Phares CR · 2025 · Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Background It is not recommended to perform tuberculin skin tests (TSTs) or interferon-γ release assays (IGRAs) in the 4 weeks following live-virus vaccination because these vaccines are thought to increase the risk of false-negative…
View details →Tang TH, Kwong RT, Chan P et al. · 2026 · HIV medicine
Introduction Two-drug regimens (2DRs) may reduce long-term drug toxicities and drug-drug interactions for people with HIV (PWH) on antiretroviral therapy (ART). This study evaluated clinical and laboratory outcomes in PWH who switched from…
View details →Rizzuto P, Gangat M, Khattab A et al. · 2026 · Journal of clinical research in pediatric endocrinology
21-hydroxylase deficiency is the most common cause of congenital adrenal hyperplasia (CAH). Salt-wasting CAH can present with life-threatening salt-wasting crises, underscoring the importance of universal newborn screening. We present a…
View details →Mooghali M, Ramachandran R, Mohammad A et al. · 2026 · Journal of the National Cancer Institute
Industry payments to physician's influence prescribing, raising concern for drugs granted accelerated approval that failed confirmatory studies. We measured industry payments for oncology drugs granted accelerated approval before and after…
View details →Bruce ATI, Faria MGBF, Andrade RLP et al. · 2026 · Revista brasileira de epidemiologia = Brazilian journal of epidemiology
Objective To analyze the factors associated with the frequency of false negative results for the RMT-TB test for the diagnosis of pulmonary tuberculosis in the state of São Paulo. Methods Cross-sectional study using pulmonary tuberculosis…
View details →Cengiz SK, Demirer E, Baysal T et al. · 2026 · Annals of Saudi medicine
Background Managing small Lung-RADS 4 pulmonary nodules is clinically challenging. While CT-guided TTFNAB is standard, its efficacy and safety for lesions ≤2 cm require further evaluation to optimize outcomes and reduce unnecessary…
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